iPTMnet Report for P53671 (LIMK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53671 / LIMK2_HUMAN
Protein Name LIM domain kinase 2
Gene Name Name: LIMK2
Organism Homo sapiens (Human)

PRO ID PR:P53671
DAG View
PRO Name LIM domain kinase 2 (human)
Definition A LIM domain kinase 2 that is encoded in the genome of human.
Short Label hLIMK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53671 (LIMK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C37 Methylation IEDB 31844290
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus   UniProt 18691976
K272 Ubiquitination PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
S283 Phosphorylation O14965 (AURKA) , Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22492986, 16820362, 15923181
S287 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S289 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17192257
S291 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
K292 Ubiquitination PhosphoSitePlus
S293 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 17192257
S297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K300 Ubiquitination PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
T372 O-Glycosylation GlyGen 30459171
K378 Ubiquitination PhosphoSitePlus
Y396 Phosphorylation IEDB 35494241
K414 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
T494 Phosphorylation O14965 (AURKA) neXtProt   PhosphoSitePlus   RLIMS-P 22492986, 16820362
T505 Phosphorylation Q5VT25 (CDC42BPA) , O14965 (AURKA) , O75116 (ROCK2) , Q13464 (ROCK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11340065, 19099536, 28581515, ...23082153, 11171090, 16505165, 22492986, 11018042
Site PTM Type PTM Enzyme Score Source PMID
S191 Phosphorylation HPRD 18691976
T210 Phosphorylation HPRD 18691976
S287 Phosphorylation HPRD 18691976, 18669648, 20068231
S289 Phosphorylation HPRD 18669648
S293 Phosphorylation HPRD 18691976, 18669648
S297 Phosphorylation HPRD 18691976
S298 Phosphorylation HPRD 18691976, 18669648
T526 Phosphorylation Q13464 (ROCK1) , Q5VT25 (CDC42BPA) HPRD 11340065, 11018042
Site PTM Type PTM Enzyme Score Source PMID
S170 Phosphorylation HPRD 18691976
T189 Phosphorylation HPRD 18691976
S266 Phosphorylation HPRD 18691976, 18669648, 20068231
S268 Phosphorylation HPRD 18669648
S272 Phosphorylation HPRD 18691976, 18669648
S276 Phosphorylation HPRD 18691976
S277 Phosphorylation HPRD 18691976, 18669648
T505 Phosphorylation Q13464 (ROCK1) , Q5VT25 (CDC42BPA) HPRD 11340065, 11018042
Site PTM Type PTM Enzyme Score Source PMID
S170 Phosphorylation HPRD 18691976
T189 Phosphorylation HPRD 18691976
S266 Phosphorylation HPRD 18691976, 18669648, 20068231
S268 Phosphorylation HPRD 18669648
S272 Phosphorylation HPRD 18691976, 18669648
S276 Phosphorylation HPRD 18691976
S277 Phosphorylation HPRD 18691976, 18669648
K653 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
T682 Phosphorylation PhosphoSitePlus


P53671 (LIMK2) as PTM Enzyme



Substrate Site Score Source PMID
P23528 (CFL1) S3 HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 11340065, 19413330, 18578522, ...18491316, 18702456, 9655398, 20058876, 19651622, 18669648, 10436159, 11171090, 16505165, 11418599, 11925442, 20068231
P60981 (DSTN) S3 PhosphoSitePlus 11171090


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048210 (hLIMK2/Phos:2) pT505 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T151 M151 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T151 A151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S168 F168 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S170 G170 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, cosmic, icgc ]
S191 G191 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T278 R278 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S283 F283 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S291 F291 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S310 R310 Biomuta DOID:1324 / lung cancer [ cosmic ]
T372 I372 Biomuta DOID:4159 / skin cancer [ cosmic ]
K679 R679 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]