iPTMnet Report for P53396 (ACLY)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53396 / ACLY_HUMAN
Protein Name ATP-citrate synthase
Gene Name Name: ACLY
Organism Homo sapiens (Human)

PRO ID PR:P53396
DAG View
PRO Name ATP-citrate synthase (human)
Definition An ATP-citrate synthase that is encoded in the genome of human.
Short Label hACLY
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53396 (ACLY) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 30397120, 34725712, 26853435, 35008409, 34019948, 35083852, 32119511, 33465208
K4 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
C20 Methylation IEDB 31844290
C20 S-Nitrosylation dbSNO 26338901
S23 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus   UniProt 15592455
K148 Ubiquitination PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
C229 Methylation IEDB 31844290
C229 S-Nitrosylation dbSNO 19483679, 2212679, 22126794
K230 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
K369 Acetylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
R379 Methylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
R389 Methylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
T447 Phosphorylation phospho.ELM   PhosphoSitePlus 2176822
S451 Phosphorylation phospho.ELM   PhosphoSitePlus 2176822
T453 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S455 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33991616, 21406692, 36269753, ...18088087, 17081983, 28689661, 25643809, 15302935, 27067055, 18669648, 21787891, 24275569, 10653665, 27015560, 23186163, 20068231
S457 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K468 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
S478 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S481 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18691976, 18669648, 24275569, 19690332, 20068231, 17924679
S484 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S489 O-Glycosylation GlyGen 33465208
T490 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 30397120, 34725712, 26853435, 35008409, 34019948, 35083852, 32119511, 33465208
T491 O-Glycosylation GlyGen 33465208
K498 Ubiquitination PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K540 Acetylation PhosphoSitePlus   UniProt 23932781
K540 Ubiquitination PhosphoSitePlus   UniProt 27664236, 23932781
K546 Acetylation PhosphoSitePlus   UniProt 19608861, 23932781
K546 Ubiquitination PhosphoSitePlus   UniProt 27664236, 23932781
K554 Acetylation PhosphoSitePlus   UniProt 19608861, 23932781
K554 Ubiquitination PhosphoSitePlus   UniProt 27664236, 23932781
K562 Ubiquitination PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K630 Acetylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K635 Acetylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus   UniProt 19369195
S649 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
Y652 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus   UniProt 19369195
S667 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
Y682 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 19369195, 16464493
R691 Methylation PhosphoSitePlus
Y692 Phosphorylation PhosphoSitePlus
Y704 Phosphorylation PhosphoSitePlus
T707 Phosphorylation PhosphoSitePlus
C742 Methylation IEDB 31844290
H760 Phosphorylation PhosphoSitePlus
C764 Methylation IEDB 31844290
K780 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y854 Phosphorylation PhosphoSitePlus
C913 Methylation IEDB 31844290
K918 Ubiquitination PhosphoSitePlus
T930 Phosphorylation PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K948 Acetylation PhosphoSitePlus   UniProt 19608861
K948 Ubiquitination PhosphoSitePlus
S952 Phosphorylation PhosphoSitePlus
K962 Acetylation PhosphoSitePlus
K962 Ubiquitination PhosphoSitePlus
K964 Methylation PhosphoSitePlus
K965 Methylation PhosphoSitePlus
K968 Acetylation PhosphoSitePlus   UniProt 19608861
K968 Ubiquitination PhosphoSitePlus
K978 Acetylation PhosphoSitePlus
K978 Ubiquitination PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
R986 Methylation PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
Y1006 Phosphorylation PhosphoSitePlus
K1012 Ubiquitination PhosphoSitePlus
Y1073 Phosphorylation PhosphoSitePlus
K1077 Acetylation PhosphoSitePlus   UniProt 19608861
K1077 Ubiquitination PhosphoSitePlus
K1080 Ubiquitination PhosphoSitePlus
Y1084 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y131 Phosphorylation HPRD 15592455
S442 Phosphorylation HPRD 20058876
T445 Phosphorylation HPRD 20058876
T447 Phosphorylation P49841 (GSK3B) HPRD 10653665, 20058876
S451 Phosphorylation P49841 (GSK3B) HPRD 10653665
T453 Phosphorylation HPRD 18669648, 17081983
S455 Phosphorylation P17612 (PRKACA) HPRD 10653665, 18767875, 18452278, ...18669648, 18088087, 19415658, 17924679
S459 Phosphorylation HPRD 18669648
S478 Phosphorylation HPRD 18669648, 20058876, 19415658
S481 Phosphorylation HPRD 17081983, 20058876, 19664994, ...19664995, 18669648, 19415658, 17924679
S484 Phosphorylation HPRD 19413330
Y682 Phosphorylation HPRD 15592455, 17016520
S1100 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y131 Phosphorylation HPRD 15592455
S442 Phosphorylation HPRD 20058876
T445 Phosphorylation HPRD 20058876
T447 Phosphorylation P49841 (GSK3B) HPRD 10653665, 20058876
S451 Phosphorylation P49841 (GSK3B) HPRD 10653665
T453 Phosphorylation HPRD 18669648, 17081983
S455 Phosphorylation P17612 (PRKACA) HPRD 10653665, 18767875, 18452278, ...18669648, 18088087, 19415658, 17924679
S459 Phosphorylation HPRD 18669648
K471 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
Y672 Phosphorylation HPRD 15592455, 17016520
S1090 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K82 R82 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K148 T148 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K230 Q230 Biomuta DOID:1324 / lung cancer [ cosmic ]
S260 R260 Biomuta DOID:1612 / breast cancer [ cosmic ]
S260 N260 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K272 I272 Biomuta DOID:1324 / lung cancer [ cosmic ]
T322 N322 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R389 W389 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S451 N451 Biomuta DOID:1319 / brain cancer [ cosmic ]
S455 Y455 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S459 A459 Biomuta DOID:4159 / skin cancer [ cosmic ]
S459 F459 Biomuta DOID:4159 / skin cancer [ cosmic ]
K468 M468 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S478 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K478 M478 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K488 M488 Biomuta DOID:2021 / placenta cancer [ cosmic ]
Y531 S531 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K546 N546 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T606 M606 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T606 S606 Biomuta DOID:4159 / skin cancer [ cosmic ]
S649 T649 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y652 H652 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S656 N656 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S667 P667 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y672 C672 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y682 C682 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y704 S704 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S839 L839 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ icgc ]
Y854 C854 Biomuta DOID:4159 / skin cancer [ cosmic ]
S979 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R986 L986 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R986 P986 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R986 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K1080 M1080 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1090 N1090 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic ]
S1100 N1100 Biomuta DOID:9256 / colorectal cancer [ cosmic ]