iPTMnet Report for P53004 (BLVRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53004 / BIEA_HUMAN
Protein Name Biliverdin reductase A precursor
Gene Name Name: BLVRA
Synonyms:BLVR,BVR;
Organism Homo sapiens (Human)

PRO ID PR:P53004
DAG View
PRO Name biliverdin reductase A (human)
Definition A biliverdin reductase A that is encoded in the genome of human.
Short Label hBLVRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53004 (BLVRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   RLIMS-P 22584576
S33 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   RLIMS-P 22584576
Y72 Phosphorylation P53004 (BLVRA) phospho.ELM   PhosphoSitePlus   RLIMS-P 15870194
Y83 Phosphorylation P53004 (BLVRA) phospho.ELM   PhosphoSitePlus   RLIMS-P 15870194
K92 Acetylation PhosphoSitePlus
K143 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S149 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus 22065579, 17639074
T174 Phosphorylation PhosphoSitePlus   UniProt 19690332
S178 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y198 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 15870194
T202 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 15870194
S230 Phosphorylation P17252 (PRKCA) , P27361 (MAPK3) , Q05655 (PRKCD) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22065579, 18463290, 18669648, ...17639074, 22584576, 20068231
K234 Methylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S237 Phosphorylation Q05655 (PRKCD) HPRD   PhosphoSitePlus   RLIMS-P 19413330, 22584576
K248 Acetylation PhosphoSitePlus   UniProt 19608861
K248 Ubiquitination PhosphoSitePlus
K253 Acetylation PhosphoSitePlus   UniProt 19608861
K253 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
Y291 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 15870194


P53004 (BLVRA) as PTM Enzyme



Substrate Site Score Source PMID
P05771 (PRKCB) T500 neXtProt   PhosphoSitePlus   Signor 17227757
P53004 (BLVRA) Y72 PhosphoSitePlus 15870194
P53004 (BLVRA) Y83 PhosphoSitePlus 15870194


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 F21 Biomuta [ cosmic ]
S149 L149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
Y198 S198 Biomuta DOID:3571 / liver cancer [ cosmic ]
K219 N219 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
K219 Q219 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S235 C235 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S235 Y235 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S235 T235 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S237 C237 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K290 T290 Biomuta DOID:363 / uterine cancer [ icgc ]