iPTMnet Report for P52895 (AKR1C2)
Protein Information
UniProt AC / UniProt ID | P52895 / AK1C2_HUMAN |
Protein Name | Aldo-keto reductase family 1 member C2 |
Gene Name | Name: AKR1C2 Synonyms:DDH2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P52895 |
PRO Name | aldo-keto reductase family 1 member C2 (human) |
Definition | An aldo-keto reductase family 1 member C2 that is encoded in the genome of human. |
Short Label | hAKR1C2 |
Category | organism-gene |
P52895 (AKR1C2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K4 | Acetylation | score1 | PhosphoSitePlus | |||
K4 | Sumoylation | score1 | PhosphoSitePlus | |||
K4 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y5 | Phosphorylation | score1 | PhosphoSitePlus | |||
K9 | Acetylation | score1 | PhosphoSitePlus | |||
K9 | Sumoylation | score1 | PhosphoSitePlus | |||
K9 | Ubiquitination | score1 | PhosphoSitePlus | |||
T23 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y24 | Phosphorylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
K33 | Ubiquitination | score1 | PhosphoSitePlus | |||
K39 | Ubiquitination | score1 | PhosphoSitePlus | |||
K68 | Acetylation | score1 | PhosphoSitePlus | |||
K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
S73 | Phosphorylation | score1 | PhosphoSitePlus | |||
K75 | Acetylation | score1 | PhosphoSitePlus | |||
K75 | Sumoylation | score1 | PhosphoSitePlus | |||
K75 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y81 | Phosphorylation | score1 | PhosphoSitePlus | |||
T82 | Phosphorylation | score1 | PhosphoSitePlus | |||
S83 | Phosphorylation | score1 | PhosphoSitePlus | |||
K84 | Acetylation | score1 | PhosphoSitePlus | |||
K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
K104 | Sumoylation | score1 | PhosphoSitePlus | |||
K104 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y110 | Phosphorylation | score1 | PhosphoSitePlus | |||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
K131 | Sumoylation | score1 | PhosphoSitePlus | |||
T141 | Phosphorylation | score1 | PhosphoSitePlus | |||
K161 | Acetylation | score1 | PhosphoSitePlus | |||
K161 | Ubiquitination | score1 | PhosphoSitePlus | |||
S162 | Phosphorylation | score1 | PhosphoSitePlus | |||
K179 | Acetylation | score1 | PhosphoSitePlus | |||
K179 | Ubiquitination | score1 | PhosphoSitePlus | |||
K183 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y184 | Phosphorylation | score1 | PhosphoSitePlus | |||
K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y196 | Phosphorylation | score1 | PhosphoSitePlus | |||
K201 | Acetylation | score1 | PhosphoSitePlus | |||
K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
K207 | Ubiquitination | score1 | PhosphoSitePlus | |||
S208 | Phosphorylation | score1 | PhosphoSitePlus | |||
K209 | Ubiquitination | score1 | PhosphoSitePlus | |||
S232 | Phosphorylation | score1 | PhosphoSitePlus | |||
K246 | Acetylation | score1 | PhosphoSitePlus | |||
K246 | Ubiquitination | score1 | PhosphoSitePlus | |||
K247 | Acetylation | score1 | PhosphoSitePlus | |||
K247 | Ubiquitination | score1 | PhosphoSitePlus | |||
K270 | Acetylation | score1 | PhosphoSitePlus | |||
K270 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y272 | Phosphorylation | score1 | PhosphoSitePlus | |||
K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y305 | Phosphorylation | score1 | PhosphoSitePlus | |||
T307 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y317 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y5 | C5 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y24 | H24 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
Y184 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K209 | N209 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |