iPTMnet Report for P52799 (EFNB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52799 / EFNB2_HUMAN
Protein Name Ephrin-B2 precursor
Gene Name Name: EFNB2
Synonyms:EPLG5,HTKL,LERK5;
Organism Homo sapiens (Human)

PRO ID PR:P52799
DAG View
PRO Name ephrin-B2 (human)
Definition An ephrin-B2 that is encoded in the genome of human.
Short Label hEFNB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52799 (EFNB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y11 Phosphorylation PhosphoSitePlus
N36 N-Glycosylation GlyGen   UniProt 23090970, 18488039, 19836338, ...29391424, 24190977
T69 Phosphorylation PhosphoSitePlus
N139 N-Glycosylation GlyGen 23090970, 24190977
T180 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T189 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T208 O-Glycosylation GlyGen 25813380
S260 Phosphorylation PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
N282 N-Glycosylation GlyGen 29391424
Y304 Phosphorylation P29323 (EPHB2) HPRD   IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 17016520, 15096211, 17389395, ...15764601, 15951569, 12606549
S308 Phosphorylation PhosphoSitePlus
Y311 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 12606549
Y316 Phosphorylation IntAct   phospho.ELM   PRO   PhosphoSitePlus 12606549, 15764601
S325 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y330 Phosphorylation HPRD   IntAct   phospho.ELM   PRO   PhosphoSitePlus 17016520, 15951569, 15764601
Y331 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047257 (hEFNB2/SigPep-/Phos:2) pY311,pY316,pY330 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S260 L260 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T264 M264 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
T264 A264 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S268 L268 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S268 P268 Biomuta DOID:4159 / skin cancer [ cosmic ]
S308 I308 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y311 C311 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y330 C330 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K332 N332 Biomuta DOID:1324 / lung cancer [ cosmic ]