iPTMnet Report for P52594 (AGFG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52594 / AGFG1_HUMAN
Protein Name Arf-GAP domain and FG repeat-containing protein 1
Gene Name Name: AGFG1
Synonyms:HRB,RAB,RIP;
Organism Homo sapiens (Human)

PRO ID PR:P52594
DAG View
PRO Name Arf-GAP domain and FG repeat-containing protein 1 (human)
Definition An Arf-GAP domain and FG repeat-containing protein 1 that is encoded in the genome of human.
Short Label hAGFG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52594 (AGFG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R18 Methylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
S138 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S142 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S142 Phosphorylation PhosphoSitePlus
S144 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S144 Phosphorylation PhosphoSitePlus
S146 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S147 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S147 Phosphorylation PhosphoSitePlus
S149 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S149 Phosphorylation PhosphoSitePlus
T151 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T151 Phosphorylation PhosphoSitePlus
T154 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T154 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K161 Methylation PhosphoSitePlus
S162 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S162 Phosphorylation PhosphoSitePlus
S167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T170 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K175 Ubiquitination PhosphoSitePlus
T177 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 18088087, ...19690332
S179 Phosphorylation PhosphoSitePlus
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 18088087, 20068231
K194 Acetylation PhosphoSitePlus
S291 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S291 Phosphorylation PhosphoSitePlus
S292 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S293 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S293 Phosphorylation PhosphoSitePlus
T298 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 28657654, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 31373491, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T298 Phosphorylation PhosphoSitePlus
T301 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T301 Phosphorylation PhosphoSitePlus
S302 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S302 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S304 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S304 Phosphorylation phospho.ELM 18669648
T307 Phosphorylation PhosphoSitePlus
S309 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S312 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
K313 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
T351 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S359 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S362 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S362 Phosphorylation PhosphoSitePlus   UniProt 23186163
S365 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S365 Phosphorylation PhosphoSitePlus
S367 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 32938750, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S368 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 32938750, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S368 Phosphorylation PhosphoSitePlus
S370 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S371 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S385 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T389 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S391 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T395 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S396 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S398 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S401 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S402 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T407 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S421 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S446 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T448 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
R456 Methylation PhosphoSitePlus
Y480 Phosphorylation PhosphoSitePlus
S481 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
S489 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 28686627, 34725712, 32119511, 32574038, 35132862, 28604694, 29485866, 20305658, 28657654, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948
T544 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
T558 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S146 Phosphorylation HPRD 18669648
T154 Phosphorylation HPRD 18669648, 20068231
S167 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231
T170 Phosphorylation HPRD 18669648, 20068231
T177 Phosphorylation HPRD 19413330, 18669648, 18088087, ...17081983, 20068231
S179 Phosphorylation HPRD 19413330, 20068231
S181 Phosphorylation HPRD 19413330, 17322306, 18088087, ...19664994, 19664995, 19651622, 18669648, 20166139, 20068231
S302 Phosphorylation HPRD 18669648
S304 Phosphorylation HPRD 18669648
Y327 Phosphorylation HPRD 17016520
S362 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K120 M120 Biomuta DOID:1612 / breast cancer [ cosmic ]
T151 A151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K194 N194 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T298 N298 Biomuta DOID:263 / kidney cancer [ cosmic ]
K313 N313 Biomuta DOID:3571 / liver cancer [ cosmic ]
K313 Q313 Biomuta DOID:1324 / lung cancer [ cosmic ]
S362 L362 Biomuta DOID:1324 / lung cancer [ cosmic ]
S398 N398 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S398 Y398 Biomuta DOID:4159 / skin cancer [ cosmic ]
S446 A446 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T448 R448 Biomuta DOID:9256 / colorectal cancer [ cosmic ]