iPTMnet Report for P51825 (AFF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51825 / AFF1_HUMAN
Protein Name AF4/FMR2 family member 1
Gene Name Name: AFF1
Synonyms:AF4,FEL,MLLT2,PBM1;
Organism Homo sapiens (Human)

PRO ID PR:P51825
DAG View
PRO Name AF4/FMR2 family member 1 (human)
Definition An AF4/FMR2 family member 1 that is encoded in the genome of human.
Short Label hAFF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51825 (AFF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y64 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
S199 Phosphorylation IEDB   PhosphoSitePlus 27920218
S206 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 19369195, 18669648, ...19690332, 20068231
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21574958, 18669648, 19369195, ...18691976
S216 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T220 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21574958, 18669648
S237 Phosphorylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K244 Acetylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S588 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 15302935, 23186163
S620 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
K681 Acetylation PhosphoSitePlus   UniProt 19608861
T697 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692
S715 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
S750 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...19690332
T755 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T766 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S798 Phosphorylation IEDB 32387766
S803 Phosphorylation PhosphoSitePlus
K809 Acetylation PhosphoSitePlus
C822 Methylation IEDB 31844290
K826 Ubiquitination PhosphoSitePlus
K831 Acetylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
K972 Acetylation PhosphoSitePlus
K973 Acetylation PhosphoSitePlus
T1039 Phosphorylation PhosphoSitePlus
T1042 Phosphorylation PhosphoSitePlus
T1166 Phosphorylation PhosphoSitePlus
T1209 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S199 Phosphorylation HPRD 18691976
S206 Phosphorylation HPRD 18691976, 18669648, 20068231
S212 Phosphorylation HPRD 18691976, 18669648, 20068231
S216 Phosphorylation HPRD 18669648
T220 Phosphorylation HPRD 18669648
T325 Phosphorylation HPRD 20068231
S588 Phosphorylation HPRD 18691976, 15302935, 20068231
T619 Phosphorylation HPRD 18691976
T697 Phosphorylation HPRD 18691976
T707 Phosphorylation HPRD 18691976
S709 Phosphorylation HPRD 18691976
S715 Phosphorylation HPRD 18691976
S734 Phosphorylation HPRD 20230923
S750 Phosphorylation HPRD 18691976, 18669648, 20068231
T755 Phosphorylation HPRD 18691976, 18669648, 20068231
T766 Phosphorylation HPRD 15302935
T1209 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S1099 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 N10 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K74 N74 Biomuta DOID:10534 / stomach cancer [ icgc ]
S83 Y83 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
T376 M376 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S620 I620 Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
S620 R620 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S667 I667 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T697 S697 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S717 N717 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S798 N798 Biomuta [ cosmic ]
K831 T831 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S837 L837 Biomuta DOID:184 / bone cancer [ cosmic ]
S847 Y847 Biomuta DOID:363 / uterine cancer [ icgc ]
S932 Y932 Biomuta DOID:363 / uterine cancer [ icgc ]
S950 F950 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K973 R973 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1042 I1042 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]