iPTMnet Report for P50990 (CCT8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50990 / TCPQ_HUMAN
Protein Name T-complex protein 1 subunit theta
Gene Name Name: CCT8
Synonyms:C21orf112,CCTQ,KIAA0002;
Organism Homo sapiens (Human)

PRO ID PR:P50990
DAG View
PRO Name T-complex protein 1 subunit theta (human)
Definition A T-complex protein 1 subunit theta that is encoded in the genome of human.
Short Label hCCT8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50990 (CCT8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
Y30 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19690332, 16497976
K37 Ubiquitination PhosphoSitePlus
T42 O-Glycosylation GlyGen 16408927, 33214551, 35138101, ...30397120, 34725712, 26853435, 32119511, 35254053, 34019948, 35083852, 32870666, 22967762, 20305658
T43 O-Glycosylation GlyGen 16408927, 33214551, 35138101, ...30397120, 34725712, 26853435, 32119511, 35254053, 34019948, 35083852, 32870666, 22967762, 20305658
K54 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
C136 Methylation IEDB 31844290
K138 Ubiquitination PhosphoSitePlus
C148 S-Nitrosylation dbSNO 19483679, 22178444
C149 S-Nitrosylation dbSNO 19483679, 22178444
S150 Phosphorylation PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus   UniProt 23186163
K171 Ubiquitination PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
C205 Methylation IEDB 31844290
S210 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus   UniProt 23186163
S216 Phosphorylation PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus   UniProt 23186163
K270 Ubiquitination PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
K296 Acetylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus   UniProt 23186163
K318 Acetylation PhosphoSitePlus   UniProt 19608861
K318 Ubiquitination PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
R378 Methylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
K400 Acetylation PhosphoSitePlus   UniProt 19608861
K400 Methylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
C430 Methylation IEDB 31844290
C430 S-Nitrosylation dbSNO 19483679
Y436 Phosphorylation PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K440 Acetylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K459 Sumoylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K466 Acetylation PhosphoSitePlus   UniProt 19608861
K466 Ubiquitination PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
Y505 Phosphorylation PhosphoSitePlus   UniProt 15592455
T512 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
K528 Acetylation PhosphoSitePlus
K528 Methylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
K534 Sumoylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus   UniProt 23186163
K539 Acetylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K540 Acetylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 18669648
Y30 Phosphorylation HPRD 16497976
Y173 Phosphorylation HPRD 20068231
T227 Phosphorylation HPRD 17924679
T232 Phosphorylation HPRD 20068231, 17924679
S233 Phosphorylation HPRD 17924679
Y505 Phosphorylation HPRD 15592455
S537 Phosphorylation HPRD 19651622, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C136 F136 Biomuta DOID:1324 / lung cancer [ cosmic ]
C205 R205 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T232 I232 Biomuta DOID:3571 / liver cancer [ cosmic ]
T293 S293 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R378 Q378 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R378 * Biomuta DOID:363 / uterine cancer [ cosmic ]
C430 R430 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y436 N436 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K439 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K466 N466 Biomuta DOID:3571 / liver cancer [ cosmic ]