iPTMnet Report for P50747 (HLCS)
Protein Information
UniProt AC / UniProt ID | P50747 / BPL1_HUMAN |
Protein Name | Biotin--protein ligase |
Gene Name | Name: HLCS |
Organism | Homo sapiens (Human) |
PRO ID | PR:P50747 |
PRO Name | biotin--protein ligase (human) |
Definition | A biotin--protein ligase that is encoded in the genome of human. |
Short Label | hHLCS |
Category | organism-gene |
P50747 (HLCS) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S79 | Phosphorylation | score1 | PhosphoSitePlus | |||
S81 | Phosphorylation | score1 | PhosphoSitePlus | |||
S124 | Phosphorylation | score1 | PhosphoSitePlus | |||
S138 | Phosphorylation | score1 | PhosphoSitePlus | |||
T146 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S147 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
Y236 | Phosphorylation | score1 | PhosphoSitePlus | |||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
S259 | Phosphorylation | score1 | PhosphoSitePlus | |||
K274 | Ubiquitination | score1 | PhosphoSitePlus | |||
S299 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K567 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y635 | Phosphorylation | score1 | PhosphoSitePlus | |||
T642 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S81 | C81 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S238 | F238 | Biomuta | DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
T642 | I642 | Biomuta | DOID:363 / uterine cancer [ icgc ] |