iPTMnet Report for P50213 (IDH3A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50213 / IDH3A_HUMAN
Protein Name Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor
Gene Name Name: IDH3A
Organism Homo sapiens (Human)

PRO ID PR:P50213
DAG View
PRO Name isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (human)
Definition An isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial that is encoded in the genome of human.
Short Label hIDH3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50213 (IDH3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
R66 Methylation PhosphoSitePlus
T69 O-Glycosylation GlyGen 34229054, 29351928
T69 Phosphorylation PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
C127 Methylation IEDB 31844290
S154 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K343 Acetylation PhosphoSitePlus   UniProt 19608861
K343 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T117 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R66 Q66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S82 L82 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc ]
K90 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T101 N101 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T101 S101 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K177 R177 Biomuta DOID:363 / uterine cancer [ icgc ]