iPTMnet Report for P49902 (NT5C2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49902 / 5NTC_HUMAN
Protein Name Cytosolic purine 5'-nucleotidase
Gene Name Name: NT5C2
Synonyms:NT5B,NT5CP,PNT5;
Organism Homo sapiens (Human)

PRO ID PR:P49902
DAG View
PRO Name cytosolic purine 5'-nucleotidase (human)
Definition A cytosolic purine 5'-nucleotidase that is encoded in the genome of human.
Short Label hNT5C2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49902 (NT5C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K344 Acetylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus   UniProt 23186163
T427 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S502 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T510 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus   UniProt 23186163
K515 Ubiquitination PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S527 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S529 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K532 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y60 Phosphorylation HPRD 20068231
S502 Phosphorylation HPRD 18669648, 20068231
S527 Phosphorylation HPRD 18669648, 20058876
S529 Phosphorylation HPRD 18669648, 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T3 A3 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S4 F4 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K26 E26 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y32 N32 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K140 * Biomuta [ cosmic ]
K140 T140 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K342 R342 Biomuta DOID:363 / uterine cancer [ icgc ]
K342 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K359 Q359 Biomuta DOID:2531 / hematologic cancer [ civic, cosmic ]
K532 R532 Biomuta DOID:3571 / liver cancer [ cosmic ]