iPTMnet Report for P49757 (NUMB)
Protein Information
UniProt AC / UniProt ID | P49757 / NUMB_HUMAN |
Protein Name | Protein numb homolog |
Gene Name | Name: NUMB Synonyms:C14orf41; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P49757 |
PRO Name | protein numb homolog (human) |
Definition | A protein numb that is encoded in the genome of human. |
Short Label | hNUMB |
Category | organism-gene |
P49757 (NUMB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S7 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 21775625 | ||
K12 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y15 | Phosphorylation | score1 | PhosphoSitePlus | |||
S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
T27 | Phosphorylation | score1 | PhosphoSitePlus | |||
K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
R53 | Methylation | score1 | PhosphoSitePlus | |||
K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
K73 | Ubiquitination | score1 | PhosphoSitePlus | |||
S91 | Phosphorylation | score1 | PhosphoSitePlus | |||
T102 | Phosphorylation | Q2M2I8 (AAK1) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 18657069 | |
R121 | Methylation | score1 | PhosphoSitePlus | |||
T187 | Phosphorylation | score1 | PhosphoSitePlus | |||
T190 | Phosphorylation | score1 | PhosphoSitePlus | |||
S194 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 27920218, 23186163 | ||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
S240 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S241 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T243 | Phosphorylation | score1 | PhosphoSitePlus | |||
S244 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
T246 | Phosphorylation | score1 | PhosphoSitePlus | |||
T251 | Phosphorylation | score1 | PhosphoSitePlus | |||
S276 | Phosphorylation | Q14012 (CAMK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 17022975, 17609107 | |
R278 | Methylation | score1 | PhosphoSitePlus | |||
S284 | Phosphorylation | score1 | PhosphoSitePlus | |||
K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
S288 | Phosphorylation | Q00535 (CDK5) | score3 | PhosphoSitePlus RLIMS-P+ | 25403733 | |
S295 | Phosphorylation | Q14012 (CAMK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 17022975, 17609107 | |
S361 | Phosphorylation | score1 | PhosphoSitePlus | |||
S425 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T436 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
S438 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 23186163, 17081983, 24275569 | ||
S448 | Phosphorylation | score1 | PhosphoSitePlus | |||
T561 | Phosphorylation | score1 | PhosphoSitePlus | |||
T631 | Phosphorylation | score1 | PhosphoSitePlus | |||
S634 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 16964243 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S7 | Phosphorylation | Q05513 (PRKCZ) | score3 | HPRD IntAct | 17203073 | |
S20 | Phosphorylation | score0 | HPRD | 20068231 | ||
S240 | Phosphorylation | score0 | HPRD | 18669648 | ||
S241 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S244 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S276 | Phosphorylation | score0 | HPRD | 17081983 | ||
S295 | Phosphorylation | Q05513 (PRKCZ) | score2 | HPRD | 18767875, 17203073 | |
T436 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983, ... | ||
S438 | Phosphorylation | score0 | HPRD | 19651622, 18767875, 17081983, ... | ||
S634 | Phosphorylation | score0 | HPRD | 20166139, 18669648, 19664994, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S7 | Phosphorylation | Q05513 (PRKCZ) | score1 | HPRD | 17203073 | |
S20 | Phosphorylation | score0 | HPRD | 20068231 | ||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
S240 | Phosphorylation | score0 | HPRD | 18669648 | ||
S241 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S244 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S276 | Phosphorylation | score0 | HPRD | 17081983 | ||
S288 | Phosphorylation | score1 | PhosphoSitePlus | |||
S295 | Phosphorylation | Q05513 (PRKCZ) | score2 | HPRD | 18767875, 17203073 | |
S361 | Phosphorylation | score1 | PhosphoSitePlus | |||
T363 | Phosphorylation | score1 | PhosphoSitePlus | |||
T367 | Phosphorylation | score1 | PhosphoSitePlus | |||
S377 | Phosphorylation | score1 | PhosphoSitePlus | |||
T388 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983, ... | ||
S390 | Phosphorylation | score0 | HPRD | 19651622, 18767875, 17081983, ... | ||
S586 | Phosphorylation | score0 | HPRD | 20166139, 18669648, 19664994, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S7 | Phosphorylation | score1 | PhosphoSitePlus | |||
S20 | Phosphorylation | score0 | HPRD | 20068231 | ||
K63 | Methylation | score1 | PhosphoSitePlus | |||
S227 | Phosphorylation | score1 | PhosphoSitePlus | |||
S229 | Phosphorylation | score0 | HPRD | 18669648 | ||
S230 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S233 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S265 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17081983 | ||
S277 | Phosphorylation | score1 | PhosphoSitePlus | |||
S284 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18767875, 17081983 | ||
T425 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19651622, 18669648, 17081983, ... | ||
S427 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17081983, 18767875, 18452278, ... | ||
T550 | Phosphorylation | score1 | PhosphoSitePlus | |||
S623 | Phosphorylation | score0 | HPRD | 20166139, 18669648, 19664994, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S20 | Phosphorylation | score0 | HPRD | 20068231 | ||
S229 | Phosphorylation | score0 | HPRD | 18669648 | ||
S230 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S233 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S265 | Phosphorylation | score0 | HPRD | 17081983 | ||
S284 | Phosphorylation | score0 | HPRD | 18767875, 17081983 | ||
T377 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983, ... | ||
S379 | Phosphorylation | score0 | HPRD | 19651622, 18767875, 17081983, ... | ||
S575 | Phosphorylation | score0 | HPRD | 20166139, 18669648, 19664994, ... |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S7 | N7 | Biomuta | DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
K73 | Q73 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
K73 | R73 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S194 | L194 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S227 | F227 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] | |
S238 | F238 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R278 | P278 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
K286 | N286 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |