iPTMnet Report for P49721 (PSMB2)
Protein Information
UniProt AC / UniProt ID | P49721 / PSB2_HUMAN |
Protein Name | Proteasome subunit beta type-2 |
Gene Name | Name: PSMB2 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P49721 |
PRO Name | proteasome subunit beta type-2 (human) |
Definition | A proteasome subunit beta type-2 that is encoded in the genome of human. |
Short Label | hPSMB2 |
Category | organism-gene |
P49721 (PSMB2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
Y3 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20230923 | ||
S23 | Phosphorylation | score1 | PhosphoSitePlus | |||
K29 | Ubiquitination | score1 | PhosphoSitePlus | |||
K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
C46 | Methylation | score1 | IEDB | 31844290 | ||
K62 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y67 | Phosphorylation | score1 | PhosphoSitePlus | |||
K68 | Acetylation | score1 | PhosphoSitePlus | |||
K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
R70 | Methylation | score1 | PhosphoSitePlus | |||
Y73 | Phosphorylation | score1 | PhosphoSitePlus | |||
S76 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
R86 | Methylation | score1 | PhosphoSitePlus | |||
C91 | S-Nitrosylation | score0 | dbSNO | 19483679 | ||
R93 | Methylation | score1 | PhosphoSitePlus | |||
Y134 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y146 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y147 | Phosphorylation | score1 | PhosphoSitePlus | |||
T148 | Phosphorylation | score1 | PhosphoSitePlus | |||
R161 | Methylation | score1 | PhosphoSitePlus | |||
K162 | Ubiquitination | score1 | PhosphoSitePlus | |||
K169 | Ubiquitination | score1 | PhosphoSitePlus | |||
S179 | Phosphorylation | score1 | PhosphoSitePlus | |||
K185 | Acetylation | score1 | PhosphoSitePlus | |||
K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
K198 | Sumoylation | score1 | PhosphoSitePlus | |||
K198 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y3 | N3 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
Y3 | C3 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S23 | I23 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K34 | N34 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K37 | N37 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
K62 | E62 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
R70 | Q70 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
R70 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] | |
R93 | W93 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S179 | T179 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] |