iPTMnet Report for P49589 (CARS1)
Protein Information
UniProt AC / UniProt ID | P49589 / SYCC_HUMAN |
Protein Name | Cysteine--tRNA ligase, cytoplasmic |
Gene Name | Name: CARS1 Synonyms:CARS; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P49589 |
PRO Name | cysteine--tRNA ligase, cytoplasmic (human) |
Definition | A cysteine--tRNA ligase, cytoplasmic that is encoded in the genome of human. |
Short Label | hCARS |
Category | organism-gene |
P49589 (CARS1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 22814378 | ||
S19 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
T24 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y32 | Phosphorylation | score1 | PhosphoSitePlus | |||
S34 | Phosphorylation | score1 | PhosphoSitePlus | |||
T36 | Phosphorylation | score1 | PhosphoSitePlus | |||
K39 | Ubiquitination | score1 | PhosphoSitePlus | |||
K48 | Acetylation | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
K49 | Acetylation | score1 | PhosphoSitePlus | |||
Y53 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y60 | Phosphorylation | score1 | PhosphoSitePlus | |||
S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
R79 | Phosphorylation | score1 | UniProt | 20068231 | ||
K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y115 | Phosphorylation | score1 | PhosphoSitePlus | |||
K134 | Ubiquitination | score1 | PhosphoSitePlus | |||
K148 | Acetylation | score1 | PhosphoSitePlus | |||
K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
K217 | Ubiquitination | score1 | PhosphoSitePlus | |||
T239 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y260 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y262 | Phosphorylation | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
K295 | Ubiquitination | score1 | PhosphoSitePlus | |||
S305 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S307 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
K327 | Ubiquitination | score1 | PhosphoSitePlus | |||
K412 | Ubiquitination | score1 | PhosphoSitePlus | |||
K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y444 | Phosphorylation | score1 | PhosphoSitePlus | |||
K482 | Ubiquitination | score1 | PhosphoSitePlus | |||
K492 | Ubiquitination | score1 | PhosphoSitePlus | |||
K503 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K503 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y528 | Phosphorylation | score1 | PhosphoSitePlus | |||
K606 | Ubiquitination | score1 | PhosphoSitePlus | |||
K640 | Ubiquitination | score1 | PhosphoSitePlus | |||
K672 | Acetylation | score1 | PhosphoSitePlus | |||
S746 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S34 | Phosphorylation | score0 | HPRD | 20068231 | ||
T239 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y260 | Phosphorylation | score0 | HPRD | 15592455 | ||
S307 | Phosphorylation | score0 | HPRD | 19664994, 20068231 | ||
S746 | Phosphorylation | score0 | HPRD | 18669648, 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S34 | Phosphorylation | score0 | HPRD | 20068231 | ||
K48 | Acetylation | score1 | PhosphoSitePlus | |||
T239 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y260 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
S307 | Phosphorylation | score0 | HPRD | 19664994, 20068231 | ||
S706 | Phosphorylation | score1 | PhosphoSitePlus | |||
K717 | Methylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S79 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648, 20068231 | ||
S117 | Phosphorylation | score0 | HPRD | 20068231 | ||
K131 | Acetylation | score1 | PhosphoSitePlus | |||
K132 | Acetylation | score1 | PhosphoSitePlus | |||
T322 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y343 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
S390 | Phosphorylation | score0 | HPRD | 19664994, 20068231 | ||
Y527 | Phosphorylation | score1 | PhosphoSitePlus | |||
S829 | Phosphorylation | score0 | HPRD | 18669648, 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T36 | S36 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K48 | E48 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y53 | H53 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] | |
K131 | E131 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y260 | * | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
Y343 | * | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
K412 | Q412 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] |