iPTMnet Report for P49327 (FASN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49327 / FAS_HUMAN
Protein Name Fatty acid synthase
Gene Name Name: FASN
Synonyms:FAS;
Organism Homo sapiens (Human)

PRO ID PR:P49327
DAG View
PRO Name fatty acid synthase (human)
Definition A fatty acid synthase that is encoded in the genome of human.
Short Label hFASN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49327 (FASN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
K12 Sumoylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus   UniProt 23186163
K70 Acetylation PhosphoSitePlus   UniProt 19608861
K70 Ubiquitination PhosphoSitePlus
S207 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18212344, ...18767875, 19664994, 19664995, 17322306, 18669648, 19415658, 20068231
T211 Phosphorylation PhosphoSitePlus
C212 S-Nitrosylation dbSNO 2212679, 22126794
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
T217 Phosphorylation HPRD 18767875
Y222 Phosphorylation HPRD   PhosphoSitePlus 18767875, 19664994
S225 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T245 Phosphorylation HPRD 19651622
T251 Phosphorylation HPRD   PhosphoSitePlus 19651622
T253 Phosphorylation HPRD   PhosphoSitePlus 19651622
K257 Acetylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S265 Phosphorylation IEDB   PhosphoSitePlus 32387766
Y277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
K298 Acetylation PhosphoSitePlus   UniProt 19608861
K298 Ubiquitination PhosphoSitePlus
C313 Methylation IEDB 31844290
T315 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...18369606, 35138101, 34725712, 26853435, 34019948, 25367160, 29351928, 35132862, 35083852, 33465208, 32119511, 34229054, 27185461
K326 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus   UniProt 19608861
K436 Ubiquitination PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
K528 Acetylation PhosphoSitePlus   UniProt 19608861
K528 Ubiquitination PhosphoSitePlus
E543 Methylation IEDB 32357974
C609 Methylation IEDB 31844290
K611 Ubiquitination PhosphoSitePlus
K631 Acetylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
C634 S-Nitrosylation dbSNO 19483679
C642 Methylation IEDB 31844290
C642 S-Nitrosylation dbSNO 19483679
K646 Acetylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
K673 Acetylation PhosphoSitePlus   UniProt 19608861
K673 Ubiquitination PhosphoSitePlus
S724 Phosphorylation HPRD 20068231
S725 Phosphorylation HPRD   PhosphoSitePlus 20068231
K772 Ubiquitination PhosphoSitePlus
K776 Acetylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
C779 Methylation IEDB 31844290
K786 Acetylation PhosphoSitePlus
K787 Acetylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
T827 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus
T898 Phosphorylation PhosphoSitePlus
K927 Ubiquitination PhosphoSitePlus
T928 Phosphorylation PhosphoSitePlus
T930 Phosphorylation PhosphoSitePlus
S974 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17322306, 18669648, 20068231
T976 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T980 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...18369606, 35138101, 34725712, 26853435, 34019948, 25367160, 29351928, 35132862, 35083852, 33465208, 32119511, 34229054, 27185461
T980 Phosphorylation PhosphoSitePlus
K992 Acetylation PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
S1028 Phosphorylation PhosphoSitePlus
T1032 Phosphorylation PhosphoSitePlus
Y1047 Phosphorylation PhosphoSitePlus
K1065 Acetylation PhosphoSitePlus
K1065 Ubiquitination PhosphoSitePlus
Y1067 Phosphorylation PhosphoSitePlus
K1072 Acetylation PhosphoSitePlus
K1072 Ubiquitination PhosphoSitePlus
S1081 Phosphorylation PhosphoSitePlus
K1116 Acetylation PhosphoSitePlus
K1116 Ubiquitination PhosphoSitePlus
C1118 S-Nitrosylation dbSNO 19483679
T1120 Phosphorylation PhosphoSitePlus
C1127 S-Nitrosylation dbSNO 19483679
C1141 Methylation IEDB 31844290
K1142 Ubiquitination PhosphoSitePlus
K1151 Acetylation PhosphoSitePlus
K1151 Ubiquitination PhosphoSitePlus
K1158 Acetylation PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1183 Phosphorylation PhosphoSitePlus
K1208 Ubiquitination PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
K1225 Ubiquitination PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus
K1239 Acetylation PhosphoSitePlus
K1239 Ubiquitination PhosphoSitePlus
K1241 Ubiquitination PhosphoSitePlus
S1254 Phosphorylation PhosphoSitePlus
S1261 Phosphorylation PhosphoSitePlus
T1273 Phosphorylation PhosphoSitePlus
Y1367 Phosphorylation PhosphoSitePlus
S1373 Phosphorylation PhosphoSitePlus
S1379 Phosphorylation PhosphoSitePlus
S1382 Phosphorylation PhosphoSitePlus
K1393 Ubiquitination PhosphoSitePlus
T1407 Phosphorylation PhosphoSitePlus
S1411 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S1421 Phosphorylation PhosphoSitePlus
K1429 Acetylation PhosphoSitePlus
K1429 Ubiquitination PhosphoSitePlus
K1444 Ubiquitination PhosphoSitePlus
C1459 Methylation IEDB 31844290
C1471 S-Nitrosylation dbSNO 22178444, 19366988, 18335467
S1479 Phosphorylation PhosphoSitePlus
Y1506 Phosphorylation PhosphoSitePlus
K1523 Acetylation PhosphoSitePlus
K1523 Ubiquitination PhosphoSitePlus
S1534 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...18369606, 35138101, 34725712, 26853435, 34019948, 25367160, 29351928, 35132862, 35083852, 33465208, 32119511, 34229054, 27185461
S1542 Phosphorylation PhosphoSitePlus
S1543 Phosphorylation PhosphoSitePlus
R1552 Methylation PhosphoSitePlus
C1558 Methylation IEDB 31844290
K1582 Acetylation PhosphoSitePlus
K1582 Ubiquitination PhosphoSitePlus
S1584 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1591 Acetylation PhosphoSitePlus
K1591 Ubiquitination PhosphoSitePlus
T1593 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1594 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1597 Phosphorylation PhosphoSitePlus
C1693 Methylation IEDB 31844290
S1701 Phosphorylation PhosphoSitePlus
K1704 Acetylation PhosphoSitePlus   UniProt 19608861
K1704 Ubiquitination PhosphoSitePlus
Y1707 Phosphorylation PhosphoSitePlus
S1723 Phosphorylation PhosphoSitePlus
K1739 Ubiquitination PhosphoSitePlus
S1747 Phosphorylation PhosphoSitePlus
K1752 Acetylation PhosphoSitePlus
K1752 Ubiquitination PhosphoSitePlus
C1759 Methylation IEDB 31844290
K1771 Acetylation PhosphoSitePlus   UniProt 19608861
K1827 Acetylation PhosphoSitePlus
K1827 Ubiquitination PhosphoSitePlus
K1847 Acetylation PhosphoSitePlus   UniProt 19608861
K1847 Ubiquitination PhosphoSitePlus
K1851 Ubiquitination PhosphoSitePlus
K1866 Ubiquitination PhosphoSitePlus
K1869 Ubiquitination PhosphoSitePlus
K1871 Acetylation PhosphoSitePlus
K1871 Ubiquitination PhosphoSitePlus
S1874 Phosphorylation PhosphoSitePlus
S1877 Phosphorylation PhosphoSitePlus
K1878 Acetylation PhosphoSitePlus
K1878 Ubiquitination PhosphoSitePlus
T1879 Phosphorylation IEDB 32387766
C1881 Methylation IEDB 31844290
K1911 Acetylation PhosphoSitePlus
K1911 Ubiquitination PhosphoSitePlus
K1927 Acetylation PhosphoSitePlus
K1927 Ubiquitination PhosphoSitePlus
S1947 Phosphorylation PhosphoSitePlus
S1948 Phosphorylation PhosphoSitePlus
K1993 Acetylation PhosphoSitePlus
K1993 Ubiquitination PhosphoSitePlus
K1995 Acetylation PhosphoSitePlus   UniProt 19608861
K1995 Ubiquitination PhosphoSitePlus
S1997 Phosphorylation PhosphoSitePlus
T1999 Phosphorylation PhosphoSitePlus
R2004 Methylation PhosphoSitePlus
C2010 Methylation IEDB 31844290
Y2034 Phosphorylation PhosphoSitePlus
R2043 Methylation PhosphoSitePlus
C2045 Methylation IEDB 31844290
K2047 Ubiquitination PhosphoSitePlus
S2123 Phosphorylation HPRD   PhosphoSitePlus 17322306
S2156 Phosphorylation PRO
S2175 Phosphorylation PhosphoSitePlus
K2186 Acetylation PhosphoSitePlus
K2186 Ubiquitination PhosphoSitePlus
S2192 Phosphorylation PhosphoSitePlus
K2193 Ubiquitination PhosphoSitePlus
S2198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18767875, ...18669648, 24275569, 20068231
C2202 S-Nitrosylation dbSNO 2212679
T2204 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 15302935, 23186163, ...16964243, 18767875, 19413330, 19664995, 17322306, 19664994, 18669648, 24275569, 19415658, 20068231, 17081983
K2206 Acetylation PhosphoSitePlus
T2215 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S2221 Phosphorylation IEDB 35494241
S2236 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S2265 Phosphorylation PhosphoSitePlus
T2268 Phosphorylation PhosphoSitePlus
Y2269 Phosphorylation PhosphoSitePlus
C2292 Methylation IEDB 31844290
C2312 Methylation IEDB 31844290
C2318 Methylation IEDB 31844290
K2354 Acetylation PhosphoSitePlus
T2356 Phosphorylation PhosphoSitePlus
K2391 Acetylation PhosphoSitePlus
K2391 Ubiquitination PhosphoSitePlus
K2406 Ubiquitination PhosphoSitePlus
R2413 Methylation PhosphoSitePlus
S2417 Phosphorylation PhosphoSitePlus
Y2424 Phosphorylation PhosphoSitePlus
Y2425 Phosphorylation PhosphoSitePlus
K2426 Acetylation PhosphoSitePlus
K2426 Ubiquitination PhosphoSitePlus
R2428 Methylation PhosphoSitePlus
Y2433 Phosphorylation PhosphoSitePlus
T2434 Phosphorylation PhosphoSitePlus
K2436 Acetylation PhosphoSitePlus
K2436 Ubiquitination PhosphoSitePlus
K2438 Acetylation PhosphoSitePlus
K2438 Ubiquitination PhosphoSitePlus
K2449 Sumoylation PhosphoSitePlus
K2449 Ubiquitination PhosphoSitePlus
K2471 Acetylation PhosphoSitePlus
K2471 Ubiquitination PhosphoSitePlus
T2483 Phosphorylation HPRD 20068231
S2488 Phosphorylation HPRD   PhosphoSitePlus 20068231
S2499 Phosphorylation HPRD   PhosphoSitePlus 20068231
S2507 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026827 (hFASN/OPantSer:1) pS2156 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y45 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S207 G207 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T211 I211 Biomuta DOID:3571 / liver cancer [ cosmic ]
S225 L225 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
T245 A245 Biomuta DOID:1324 / lung cancer [ cosmic ]
S279 L279 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S279 P279 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y289 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
C313 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T315 A315 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T315 P315 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K326 R326 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K436 N436 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
E543 K543 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
C642 Y642 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S724 G724 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K897 N897 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T898 A898 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
T898 M898 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T928 S928 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1028 R1028 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1141 F1141 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1174 T1174 Biomuta DOID:363 / uterine cancer [ icgc ]
S1183 L1183 Biomuta DOID:1319 / brain cancer [ icgc ]
K1208 M1208 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1237 I1237 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1382 F1382 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1382 Y1382 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1421 C1421 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1444 M1444 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1506 C1506 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1534 R1534 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1552 H1552 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1584 Y1584 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1584 F1584 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S1747 A1747 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1771 R1771 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1879 I1879 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1911 N1911 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1947 N1947 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1993 N1993 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1995 E1995 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1995 N1995 Biomuta DOID:184 / bone cancer [ cosmic ]
S1997 R1997 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1999 A1999 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R2043 C2043 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C2045 Y2045 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2047 N2047 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C2202 Y2202 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K2206 M2206 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S2221 F2221 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2236 F2236 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2265 N2265 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C2292 S2292 Biomuta DOID:363 / uterine cancer [ icgc ]
C2292 Y2292 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K2406 R2406 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R2413 C2413 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R2428 H2428 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T2483 M2483 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2507 N2507 Biomuta DOID:10283 / prostate cancer [ cosmic ]