Protein Information

Cytoscape View


UniProt AC / UniProt ID P49116 / NR2C2_HUMAN
Protein Name Nuclear receptor subfamily 2 group C member 2
Gene Name Name: NR2C2
Synonyms:TAK1,TR4;
Organism Homo sapiens (Human)

PRO ID PR:P49116
DAG View
PRO Name nuclear receptor subfamily 2 group C member 2 (human)
Definition A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human.
Short Label hNR2C2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49116 (NR2C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 16887930, 23186163, 19690332, ...20068231
S46 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
S55 Phosphorylation PhosphoSitePlus   RLIMS-P 16887930
K63 Ubiquitination PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 16887930, 23186163, 20068231
S72 O-Glycosylation GlyGen 31492838, 35289036, 35254053
S73 O-Glycosylation GlyGen 31492838, 35289036, 35254053
S98 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
Y116 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T224 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T226 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K231 Acetylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
T322 O-Glycosylation GlyGen 31492838, 35289036, 35254053
T322 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus   Signor 21478464
S351 Phosphorylation Q13131 (PRKAA1) Signor 21478464
T352 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 20068231
T13 Phosphorylation HPRD 20068231
S19 Phosphorylation HPRD   PhosphoSitePlus 20068231
S65 Phosphorylation HPRD 20068231
S74 Phosphorylation HPRD 20068231
S87 Phosphorylation HPRD 18691976, 19007248, 20068231
S117 Phosphorylation HPRD 20068231
S238 Phosphorylation HPRD 18669648, 20068231
T243 Phosphorylation HPRD 18669648
T245 Phosphorylation HPRD 18669648
T371 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T13 I13 Biomuta DOID:4159 / skin cancer [ cosmic ]
S46 T46 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S65 T65 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S68 F68 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S68 V68 Biomuta [ cosmic ]
S87 V87 Biomuta [ cosmic ]
S87 F87 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]