iPTMnet Report for P48681 (NES)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48681 / NEST_HUMAN
Protein Name Nestin
Gene Name Name: NES
ORFNames:Nbla00170;
Organism Homo sapiens (Human)

PRO ID PR:P48681
DAG View
PRO Name nestin (human)
Definition A nestin that is encoded in the genome of human.
Short Label hNES
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48681 (NES) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
Y22 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
T304 Phosphorylation HPRD 20068231
S311 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T315 Phosphorylation Q00535 (CDK5) , P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 12832492, 18669648, 11278541, ...20068231
S320 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K321 Ubiquitination PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19664994, ...19664995, 19691289, 18669648
K330 Ubiquitination PhosphoSitePlus
T338 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19664995, ...20068231
S346 Phosphorylation HPRD   PhosphoSitePlus 20068231
S352 Phosphorylation HPRD   PhosphoSitePlus 19664995, 20068231
T354 Phosphorylation HPRD   phospho.ELM 17081983, 20068231
S355 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664995, 20068231
S358 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 20068231
T363 Phosphorylation HPRD 20068231
T366 Phosphorylation HPRD 20068231
T382 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995, 20068231
T384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995, 20068231
S387 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T388 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T393 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S398 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19664995, 20068231
S413 Phosphorylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
S455 Phosphorylation HPRD 20068231
T456 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD   PhosphoSitePlus 20068231
S465 Phosphorylation HPRD 20068231
S471 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19664995, 18669648, ...24275569, 20068231
S475 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
S476 Phosphorylation PhosphoSitePlus   UniProt 24275569
S484 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
T545 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S548 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19664994, ...19664995, 18669648, 20068231
S556 Phosphorylation PhosphoSitePlus
S564 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T567 Phosphorylation PhosphoSitePlus
S578 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 19664994, ...21406692
T585 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
S588 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S627 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S680 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664995, 19651622, 20166139, 20068231
T693 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S746 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
T757 Phosphorylation PhosphoSitePlus
S768 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664995, 19691289, 19651622, 18669648, 20068231, 24275569, 20166139, 18452278, 27869121
T776 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus   UniProt 21406692
K808 Ubiquitination PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
K811 Sumoylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus   UniProt 21406692
T823 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus   UniProt 21406692
T839 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
S842 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
T845 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
T851 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S891 Phosphorylation HPRD   PhosphoSitePlus 19664995
S894 Phosphorylation PhosphoSitePlus   UniProt 21406692
S905 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
K911 Ubiquitination PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus   UniProt 21406692
K925 Ubiquitination PhosphoSitePlus
Y928 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S931 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S934 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664994, 19664995
S945 Phosphorylation PhosphoSitePlus
S965 Phosphorylation HPRD   PhosphoSitePlus 19664994
S1016 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 24275569
S1030 Phosphorylation PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
S1175 Phosphorylation PhosphoSitePlus
Y1225 Phosphorylation PhosphoSitePlus
S1261 Phosphorylation UniProt 21406692
S1282 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1286 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 15345747
T1299 Phosphorylation Q00535 (CDK5) HPRD   neXtProt   phospho.ELM 12832492
S1307 Phosphorylation PhosphoSitePlus
S1310 Phosphorylation PhosphoSitePlus
S1347 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 19664994
S1409 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18452278
S1418 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 18452278
S1441 Phosphorylation HPRD   PhosphoSitePlus 19664995
S1442 Phosphorylation PhosphoSitePlus
S1445 Phosphorylation HPRD   PhosphoSitePlus 19664995
S1450 Phosphorylation HPRD   PhosphoSitePlus 19664995, 20068231
S1451 Phosphorylation HPRD   PhosphoSitePlus 19664995
S1452 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664995
S1464 Phosphorylation PhosphoSitePlus
S1472 Phosphorylation PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1498 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1502 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
S1571 Phosphorylation HPRD 17081983
S1577 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S1585 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1589 Phosphorylation PhosphoSitePlus
S1590 Phosphorylation PhosphoSitePlus
K1605 Ubiquitination PhosphoSitePlus
S1615 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1617 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 20068231, ...17081983
S1618 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 20068231, ...17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S294 F294 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S323 F323 Biomuta DOID:4159 / skin cancer [ cosmic ]
S325 G325 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T338 I338 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T363 I363 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T382 I382 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S465 F465 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S471 I471 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S475 Y475 Biomuta DOID:1324 / lung cancer [ cosmic ]
S475 F475 Biomuta DOID:4159 / skin cancer [ cosmic ]
K507 T507 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T545 P545 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T545 I545 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S548 Y548 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T585 A585 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S627 F627 Biomuta DOID:4159 / skin cancer [ cosmic ]
S638 Y638 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S680 Y680 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ]
S746 Y746 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T757 I757 Biomuta DOID:4362 / cervical cancer [ icgc ]
S790 Y790 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K808 N808 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S820 T820 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T823 P823 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S831 Y831 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S842 C842 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S891 L891 Biomuta [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S891 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S894 Y894 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S894 T894 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S905 C905 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S905 Y905 Biomuta DOID:363 / uterine cancer [ icgc ]
S945 F945 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1030 R1030 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1282 N1282 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1307 C1307 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1310 F1310 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1409 Y1409 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S1418 R1418 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1418 G1418 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1492 C1492 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1492 I1492 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1502 Y1502 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1502 C1502 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1571 F1571 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1590 Y1590 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]