iPTMnet Report for P48643 (CCT5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48643 / TCPE_HUMAN
Protein Name T-complex protein 1 subunit epsilon
Gene Name Name: CCT5
Synonyms:CCTE,KIAA0098;
Organism Homo sapiens (Human)

PRO ID PR:P48643
DAG View
PRO Name T-complex protein 1 subunit epsilon (human)
Definition A T-complex protein 1 subunit epsilon that is encoded in the genome of human.
Short Label hCCT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48643 (CCT5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
S3 Phosphorylation PhosphoSitePlus
Y12 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus   UniProt 21406692
R27 Methylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K42 Sumoylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
R49 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
R132 Methylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
K160 Sumoylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K176 Sumoylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
C181 S-Nitrosylation dbSNO 19483679
K210 Sumoylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K226 Sumoylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K263 Acetylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
K265 Sumoylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K282 Acetylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus   UniProt 23186163
K368 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
C377 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K378 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K399 Acetylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
C407 Methylation IEDB 31844290
C407 S-Nitrosylation dbSNO 19483679
K439 Ubiquitination PhosphoSitePlus
C440 Methylation IEDB 31844290
S463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K496 Acetylation PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K502 Sumoylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
R534 Methylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 19651622, 20068231
T509 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y12 C12 Biomuta DOID:363 / uterine cancer [ icgc ]
S26 T26 Biomuta DOID:1324 / lung cancer [ icgc ]
R27 S27 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K35 E35 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K150 N150 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K150 R150 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K160 N160 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K247 N247 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C407 S407 Biomuta DOID:1324 / lung cancer [ cosmic ]
K496 R496 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S518 Y518 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R534 C534 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R534 H534 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K535 R535 Biomuta DOID:4362 / cervical cancer [ cosmic ]