iPTMnet Report for P48637 (GSS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48637 / GSHB_HUMAN
Protein Name Glutathione synthetase
Gene Name Name: GSS
Organism Homo sapiens (Human)

PRO ID PR:P48637
DAG View
PRO Name glutathione synthetase (human)
Definition A glutathione synthetase that is encoded in the genome of human.
Short Label hGSS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48637 (GSS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K12 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
R230 Methylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
R252 Methylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K443 Ubiquitination PhosphoSitePlus
T451 Phosphorylation IEDB 35494241
K452 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T147 Phosphorylation HPRD 20068231
S151 Phosphorylation HPRD 20068231
T238 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31350 (RRM2) T33 P48637 (GSS) inhibited_association eFIP 33372599


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:1319 / brain cancer [ cosmic ]
S137 T137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S181 Y181 Biomuta DOID:263 / kidney cancer [ cosmic ]
S181 F181 Biomuta DOID:4159 / skin cancer [ cosmic ]
R252 Q252 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y375 C375 Biomuta DOID:1324 / lung cancer [ cosmic ]
K443 T443 Biomuta DOID:9256 / colorectal cancer [ cosmic ]