iPTMnet Report for P48507 (GCLM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48507 / GSH0_HUMAN
Protein Name Glutamate--cysteine ligase regulatory subunit
Gene Name Name: GCLM
Synonyms:GLCLR;
Organism Homo sapiens (Human)

PRO ID PR:P48507
DAG View
PRO Name glutamate--cysteine ligase regulatory subunit (human)
Definition A glutamate--cysteine ligase regulatory subunit that is encoded in the genome of human.
Short Label hGCLM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48507 (GCLM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Sumoylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
C35 S-Nitrosylation dbSNO 22178444
K49 Ubiquitination PhosphoSitePlus
C72 S-Nitrosylation dbSNO 19483679
K80 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K158 Sumoylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K205 Sumoylation PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 19608861
K263 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K34 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K80 Q80 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K158 N158 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]