iPTMnet Report for P47897 (QARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P47897 / SYQ_HUMAN
Protein Name Glutamine--tRNA ligase
Gene Name Name: QARS1
Synonyms:QARS;
Organism Homo sapiens (Human)

PRO ID PR:P47897
DAG View
PRO Name glutamine--tRNA ligase (human)
Definition A glutamine--tRNA ligase that is encoded in the genome of human.
Short Label hQARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P47897 (QARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S6 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
T38 Phosphorylation IEDB 35494241
T47 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
S70 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 32387766, 27869121
S74 Phosphorylation PhosphoSitePlus
S78 O-Glycosylation GlyGen 23301498, 35138101, 30397120, ...34725712, 34019948, 35083852, 32870666, 28510447, 33465208
S88 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
R201 Methylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
R225 Methylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K254 Methylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus   UniProt 19608861
K366 Ubiquitination PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K412 Acetylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K421 Acetylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
C456 Methylation IEDB 31844290
C478 Methylation IEDB 31844290
Y491 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
S495 Phosphorylation PhosphoSitePlus   UniProt 23186163
K496 Ubiquitination PhosphoSitePlus
K498 Acetylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
T520 Phosphorylation PhosphoSitePlus
C556 Methylation IEDB 31844290
T564 Phosphorylation PhosphoSitePlus
K586 Acetylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K620 Acetylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K628 Acetylation PhosphoSitePlus
K628 Methylation PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
C730 Methylation IEDB 31844290
K740 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K769 Acetylation PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 20068231
T11 Phosphorylation HPRD 20068231
S16 Phosphorylation HPRD 20068231
S70 Phosphorylation HPRD 18669648
Y491 Phosphorylation HPRD 15592455, 18083107
T505 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S6 P6 Biomuta DOID:1319 / brain cancer [ cosmic ]
K25 N25 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y57 C57 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R201 W201 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
R201 Q201 Biomuta DOID:363 / uterine cancer [ icgc ]
R225 W225 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
K292 T292 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T520 M520 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C556 F556 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
C730 Y730 Biomuta DOID:1612 / breast cancer [ cosmic ]