Protein Information

Cytoscape View


UniProt AC / UniProt ID P47809 / MP2K4_MOUSE
Protein Name Dual specificity mitogen-activated protein kinase kinase 4
Gene Name Name: Map2k4
Synonyms:Jnkk1,Mek4,Mkk4,Prkmk4,Sek1,Serk1,Skk1;
Organism Mus musculus (Mouse)

PRO ID PR:P47809
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 4 (mouse)
Definition A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of mouse.
Short Label mMAP2K4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P47809 (Map2k4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K52 Ubiquitination PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
R56 Methylation PhosphoSitePlus   UniProt 24129315
S78 Phosphorylation PhosphoSitePlus 25594179
S78 Phosphorylation P31750 (Akt1) PhosphoSitePlus 25594179
S82 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus   UniProt 21183079
T96 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
C244 S-Nitrosylation dbSNO 16418269
S255 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21183079, 15833743, 25594179
S255 Phosphorylation Q60700 (Map3k12) PhosphoSitePlus 25594179
T259 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21183079, 15833743, 25594179
T259 Phosphorylation Q60700 (Map3k12) PhosphoSitePlus 25594179
T389 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus


P47809 (Map2k4) as PTM Enzyme



Substrate Site Score Source PMID
Q91Y86 (Mapk8) T183 PhosphoSitePlus 25594179
Q91Y86 (Mapk8) Y185 PhosphoSitePlus 25594179