iPTMnet Report for P46940 (IQGAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46940 / IQGA1_HUMAN
Protein Name Ras GTPase-activating-like protein IQGAP1
Gene Name Name: IQGAP1
Synonyms:KIAA0051;
Organism Homo sapiens (Human)

PRO ID PR:P46940
DAG View
PRO Name Ras GTPase-activating-like protein IQGAP1 (human)
Definition A Ras GTPase-activating-like protein IQGAP1 that is encoded in the genome of human.
Short Label hIQGAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46940 (IQGAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 20068231, 22814378, 22223895, ...25944712
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
Y17 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
C45 Methylation IEDB 31844290
K51 Ubiquitination PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   RLIMS-P 25928398
K88 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 33087447, 18707149
K174 Ubiquitination PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S256 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35008409, 34725712, 26853435, 29351928, 34019948
K266 Ubiquitination PhosphoSitePlus
S330 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 16964243, ...15302935, 18669648, 25928398, 19415658, 20068231
R336 Methylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
T435 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35008409, 34725712, 26853435, 29351928, 34019948
T435 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus   RLIMS-P 31431460
K503 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
Y654 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 33087447
T663 Phosphorylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K684 Acetylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
Y694 Phosphorylation PhosphoSitePlus
Y695 Phosphorylation PhosphoSitePlus
Y697 Phosphorylation PhosphoSitePlus
S730 Phosphorylation HPRD 20068231
Y736 Phosphorylation HPRD   PhosphoSitePlus 20068231
C781 Methylation IEDB 31844290
R787 Methylation PhosphoSitePlus
R798 Methylation PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation PhosphoSitePlus   RLIMS-P 33087447
K856 Ubiquitination PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K922 Methylation PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
K935 Ubiquitination PhosphoSitePlus
K942 Methylation PhosphoSitePlus
K942 Ubiquitination PhosphoSitePlus
K953 Ubiquitination PhosphoSitePlus
K959 Acetylation PhosphoSitePlus
K959 Ubiquitination PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
K963 Acetylation PhosphoSitePlus
K965 Acetylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
K1027 Acetylation PhosphoSitePlus
K1027 Ubiquitination PhosphoSitePlus
T1028 Phosphorylation PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
K1083 Ubiquitination PhosphoSitePlus
K1088 Acetylation PhosphoSitePlus
K1088 Methylation PhosphoSitePlus
K1088 Ubiquitination PhosphoSitePlus
Y1095 Phosphorylation PhosphoSitePlus
K1096 Methylation PhosphoSitePlus
K1096 Ubiquitination PhosphoSitePlus
S1097 Phosphorylation PhosphoSitePlus
K1111 Ubiquitination PhosphoSitePlus
Y1114 Phosphorylation PhosphoSitePlus
K1128 Ubiquitination PhosphoSitePlus
S1133 Phosphorylation PhosphoSitePlus
R1136 Methylation PhosphoSitePlus
K1144 Acetylation PhosphoSitePlus
K1144 Ubiquitination PhosphoSitePlus
S1147 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1151 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1152 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1155 Ubiquitination PhosphoSitePlus
Y1158 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1165 Ubiquitination PhosphoSitePlus
K1168 Ubiquitination PhosphoSitePlus
K1174 Acetylation PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
T1218 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus
K1230 Acetylation PhosphoSitePlus
K1230 Ubiquitination PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus
K1261 Acetylation PhosphoSitePlus
R1263 Methylation PhosphoSitePlus
R1264 Methylation PhosphoSitePlus
Y1284 Phosphorylation PhosphoSitePlus
S1285 Phosphorylation PhosphoSitePlus
T1359 Phosphorylation HPRD 20068231
K1389 Ubiquitination PhosphoSitePlus
T1403 Phosphorylation HPRD   PhosphoSitePlus 18452278
T1434 Phosphorylation PhosphoSitePlus   RLIMS-P 25928398
S1441 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27815503, 15695813, 18669648, ...28739799
K1442 Ubiquitination PhosphoSitePlus
S1443 Phosphorylation P17252 (PRKCA) , Q02156 (PRKCE) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21349850, 23186163, 15695813, ...28739799, 27815503, 18669648, 15355962, 20068231
K1445 Acetylation PhosphoSitePlus
K1445 Ubiquitination PhosphoSitePlus
S1448 Phosphorylation PhosphoSitePlus
T1451 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1464 Ubiquitination PhosphoSitePlus
K1465 Acetylation PhosphoSitePlus
K1465 Ubiquitination PhosphoSitePlus
T1467 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1475 Ubiquitination PhosphoSitePlus
K1477 Acetylation PhosphoSitePlus
K1477 Ubiquitination PhosphoSitePlus
Y1478 Phosphorylation PhosphoSitePlus
K1505 Ubiquitination PhosphoSitePlus
T1509 Phosphorylation PhosphoSitePlus
Y1510 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 33087447
S1515 Phosphorylation PhosphoSitePlus
K1516 Ubiquitination PhosphoSitePlus
Y1526 Phosphorylation PhosphoSitePlus
Y1527 Phosphorylation PhosphoSitePlus
K1528 Acetylation PhosphoSitePlus
K1528 Ubiquitination PhosphoSitePlus
K1532 Acetylation PhosphoSitePlus
K1532 Ubiquitination PhosphoSitePlus
C1534 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S1540 Phosphorylation PhosphoSitePlus
K1541 Ubiquitination PhosphoSitePlus
K1547 Acetylation PhosphoSitePlus
K1552 Acetylation PhosphoSitePlus
K1555 Acetylation PhosphoSitePlus
K1558 Acetylation PhosphoSitePlus
S1560 Phosphorylation PhosphoSitePlus
K1562 Acetylation PhosphoSitePlus
K1562 Ubiquitination PhosphoSitePlus
K1571 Acetylation PhosphoSitePlus
K1571 Ubiquitination PhosphoSitePlus
K1604 Ubiquitination PhosphoSitePlus
Y1655 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46940 (IQGAP1) S1441 P63000 (RAC1) increased_association eFIP 28739799
Phosphorylation Q9H0H5 (RACGAP1) T249 P46940 (IQGAP1) increased_association eFIP 24019536


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 P19 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K51 N51 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y77 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K88 T88 Biomuta DOID:184 / bone cancer [ cosmic ]
Y96 C96 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y96 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K130 T130 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K130 N130 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K174 N174 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T178 I178 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S256 A256 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K266 N266 Biomuta DOID:3571 / liver cancer [ cosmic ]
R336 G336 Biomuta DOID:1612 / breast cancer [ cosmic ]
S360 N360 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y654 C654 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y736 H736 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R787 T787 Biomuta DOID:4159 / skin cancer [ cosmic ]
R798 W798 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
S814 F814 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K856 M856 Biomuta DOID:3571 / liver cancer [ cosmic ]
S932 F932 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K935 E935 Biomuta DOID:1324 / lung cancer [ cosmic ]
S962 I962 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1020 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1057 N1057 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1057 T1057 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1147 L1147 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1152 F1152 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1165 N1165 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1264 W1264 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R1264 Q1264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1389 E1389 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1441 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1509 I1509 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1509 A1509 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1516 N1516 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1547 R1547 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1558 R1558 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1560 Y1560 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]