iPTMnet Report for P46937 (YAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46937 / YAP1_HUMAN
Protein Name Transcriptional coactivator YAP1
Gene Name Name: YAP1
Synonyms:YAP65;
Organism Homo sapiens (Human)

PRO ID PR:P46937
DAG View
PRO Name transcriptional coactivator YAP1 (human)
Definition A transcriptional coactivator YAP1 that is encoded in the genome of human.
Short Label hYAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46937 (YAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation PhosphoSitePlus   RLIMS-P 32271880
S61 Phosphorylation Q13131 (PRKAA1) , Q15208 (STK38) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 25751139, ...18158288, 32493454, 17974916, 30139767, 35103997, 25180175, 18669648, 25601544, 20068231
T63 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32271880, 18669648, 20068231
K76 Ubiquitination PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus   RLIMS-P 32271880
T83 O-Glycosylation GlyGen 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
T83 Phosphorylation PhosphoSitePlus   RLIMS-P 32271880
K90 Ubiquitination PhosphoSitePlus
S94 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 25751140, 25751139, 32271880
K97 Acetylation PhosphoSitePlus
K97 Sumoylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S109 O-Glycosylation GlyGen   PhosphoSitePlus 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
S109 Phosphorylation Q05513 (PRKCZ) , Q15208 (STK38) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 17081983, 18158288, ...32493454, 18220336, 17974916, 25660024, 30139767, 25601544, 32271880, 18669648, 32365528, 20068231
T110 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   RLIMS-P 32271880, 25660024
T114 Phosphorylation PhosphoSitePlus
T119 Phosphorylation P06493 (CDK1) , P45984 (MAPK9) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21364637, 25605730, 24101154, ...23186163, 20068231
S127 Phosphorylation Q15208 (STK38) , P31749 (AKT1) , Q9NRM7 (LATS2) , Q13188 (STK3) , Q9Y2H1 (STK38L) , O95835 (LATS1) IEDB   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28725753, 29136529, 31619268, ...25751140, 30139767, 30504771, 29758328, 21832154, 21945154, 30404014, 29895829, 29725063, 33416116, 26269582, 30446657, 29212185, 35713503, 33504879, 36374802, 27488962, 20823509, 33707576, 21233212, 31076104, 22614006, 22658639, 31139191, 33277245, 31208368, 29154888, 25362852, 31669263, 30833665, 25751139, 18640976, 28827520, 29296196, 24040060, 26876920, 27911857, 32219176, 33672268, 34206989, 32210573, 21730131, 30935014, 26364602, 32205868, 33014146, 33218077, 24621512, 28708445, 22329991, 28406163, 35015027, 27380321, 28815883, 32493454, 27336605, 31477715, 21214929, 31487690, 33897882, 26625308, 32457342, 29093443, 26265440, 30948712, 32322664, 21224387, 17974916, 31693448, 33032653, 29903769, 27669292, 31627466, 30824374, 32894161, 31142342, 24356468, 29339449, 28464980, 23928732, 33777675, 29909276, 26567630, 28923839, 33571521, 29891922, 27034169, 28454447, 30272278, 31649888, 22761457, 27634386, 28969054, 28470935, 25317030, 30565133, 30618636, 19878874, 28239148, 33628300, 36115593, 27556512, 31827075, 25393475, 31296870, 22884261, 12535517, 29535383, 27871934, 26625714, 28951205, 32210629, 30865227, 30631061, 32271880, 25601544, 27462448, 28332498, 23727052, 29562176, 33937255, 28420424, 24525530, 28098159, 32589311, 18158288, 31455378, 28339095, 31015465, 30037330, 28102225, 27144834, 20153295, 28757481, 34343153, 31100067, 35586495, 27555231, 27566107, 26843620, 31926547, 31145543, 31848261, 23708000, 18669648, 32707998, 18369314, 31835563, 28671675, 31788086, 27324437, 28169360, 27065882, 35358489, 22863277, 33420363, 27206784, 29487715, 27476430, 31690112, 23857250, 27205883, 26417066, 26806348, 27203549, 30466467, 28076850, 20048001, 20729916, 32848033, 27907036, 31659153, 31307004, 27869121, 30566960, 29496737, 24509725, 33097058, 29228705, 29069755, 30250159, 32231000, 27409837, 27000077, 28745364, 27457617, 18725387, 30574018, 27009203, 30559289, 29066438, 29930727, 28376152, 26967905, 28065575, 27334574, 31963871, 32711570, 27030211, 23593160, 21909427, 32483419, 31717606
S128 Phosphorylation Q9UBE8 (NLK) phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 18669648, 24275569, 27979971
S131 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32271880, 18669648, 32493454, ...24275569
S138 Phosphorylation P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21364637, 17081983, ...20068231
T141 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T143 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 35705994
T145 Phosphorylation PhosphoSitePlus
S149 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T154 Phosphorylation P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21364637
T156 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S163 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 32493454
S164 Phosphorylation Q15208 (STK38) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 18158288, 17974916, 30139767, ...25601544, 18669648
K181 Ubiquitination PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus   RLIMS-P 27428284
K204 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
T241 O-Glycosylation GlyGen   PhosphoSitePlus 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
T241 Phosphorylation RLIMS-P 33897873
K252 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S276 Phosphorylation PhosphoSitePlus
K280 Sumoylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S289 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 25605730, ...24101154, 18669648, 20068231
S300 Phosphorylation PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S336 O-Glycosylation GlyGen 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
S340 Phosphorylation PhosphoSitePlus
K342 Methylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
S350 O-Glycosylation GlyGen 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
T354 Phosphorylation PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
S366 O-Glycosylation GlyGen 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
S366 Phosphorylation PhosphoSitePlus
S367 Phosphorylation P45984 (MAPK9) , P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 21364637, 25605730, ...24101154, 18669648, 20068231
S371 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17525332, 33571521
T376 O-Glycosylation GlyGen 28474680, 34155345, 35254053, ...34019948, 29100056, 30620550, 31373491
S381 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32493454, 20048001, 23186163, ...30139767
S382 Phosphorylation PhosphoSitePlus   UniProt 23186163
S388 Phosphorylation PhosphoSitePlus   UniProt 23186163
T390 Phosphorylation PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus
S397 Phosphorylation O95835 (LATS1) , Q9NRM7 (LATS2) PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29709009, 28169360, 30833665, ...36374802, 33628300, 33707576, 26625714, 17974916, 31160567, 28969054, 28076850, 30948712, 20048001, 30559289, 18158288, 32848033, 26417066, 31659153, 30143543
T398 Phosphorylation PhosphoSitePlus
S400 Phosphorylation P48730 (CSNK1D) , P49674 (CSNK1E) PhosphoSitePlus   Signor   UniProt 20048001, 23431053, 24715453
S403 Phosphorylation P49674 (CSNK1E) , P48730 (CSNK1D) PhosphoSitePlus   RLIMS-P   Signor   UniProt 28481329, 20048001, 23431053, ...24715453
S405 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor   UniProt 18280240
T412 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33571521, 21364637
S419 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus   RLIMS-P 34343821
Y444 Phosphorylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 20729916
K494 Methylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K497 Methylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S127 Phosphorylation PR:000003057 (conventional protein kinase C) , PR:000029189 (AKT kinase) PRO 20153295, 21214929, 21945154
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation O95835 (LATS1) PhosphoSitePlus 20048001
T63 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S109 Phosphorylation O95835 (LATS1) PhosphoSitePlus 20048001
T110 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
S127 Phosphorylation Q9NRM7 (LATS2) , O95835 (LATS1) PhosphoSitePlus 18565851, 20048001, 21909427
S128 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation O95835 (LATS1) PhosphoSitePlus 20048001
S289 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S381 Phosphorylation O95835 (LATS1) PhosphoSitePlus 20048001
S384 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus 20048001
S387 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
R289 Methylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
Y357 Phosphorylation PR:P00519 (hABL1) PRO   PhosphoSitePlus 21945154, 21214929
T362 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049715 (hYAP1/Phos:3) pS61,pS109,pS127,pS164,pS397 PRO
PR:000037510 (hYAP1/Phos:1) pS127 PR:000003057 (conventional protein kinase C) PRO 20153295, 21214929, 21945154
PR:000037510 (hYAP1/Phos:1) pS127 PR:000029189 (AKT kinase) PRO 20153295, 21214929, 21945154
PR:000037508 (hYAP1/iso:3/Phos:1) pY357 PR:P00519 (hABL1) PRO 21214929, 21945154


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35240 (NF2) S518 P46937 (YAP1) decreased_association eFIP 28972170
Phosphorylation Q4VCS5 (AMOT) T750 P46937 (YAP1) inhibited_association eFIP 27321186


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037507 (hYAP1/iso:3/UnPhos:1) Interaction PR:O15350 (hTP73) PRO 21214929, 21562856
PR:000037508 (hYAP1/iso:3/Phos:1) increased Interaction PR:O15350 (hTP73) PRO 21214929, 21562856
PR:000037510 (hYAP1/Phos:1) decreased Interaction PR:O15350 (hTP73) PRO 21945154
PR:000037510 (hYAP1/Phos:1) Interaction PR:000003237 (fam:14-3-3) PRO 21214929


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 W61 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic, cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K102 R102 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S105 P105 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S109 N109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T110 S110 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T119 S119 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S127 F127 Biomuta DOID:4159 / skin cancer [ cosmic ]
S138 F138 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T145 I145 Biomuta DOID:4159 / skin cancer [ cosmic ]
T145 S145 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T154 A154 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S163 F163 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S164 F164 Biomuta DOID:4159 / skin cancer [ cosmic ]
S227 L227 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S236 G236 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S238 R238 Biomuta DOID:4159 / skin cancer [ cosmic ]
S274 G274 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S276 R276 Biomuta DOID:4159 / skin cancer [ cosmic ]
S276 N276 Biomuta DOID:4362 / cervical cancer [ icgc ]
R289 W289 Biomuta [ cosmic ]
S300 P300 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K315 R315 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S317 F317 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S340 A340 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S350 N350 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S351 F351 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T354 A354 Biomuta DOID:4159 / skin cancer [ cosmic ]
S367 F367 Biomuta DOID:4159 / skin cancer [ cosmic ]
T376 A376 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T376 P376 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S388 I388 Biomuta DOID:363 / uterine cancer [ cosmic ]
T390 I390 Biomuta DOID:1319 / brain cancer [ cosmic ]
T398 A398 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S405 G405 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S436 T436 Biomuta DOID:1612 / breast cancer [ cosmic ]