iPTMnet Report for P46778 (RPL21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46778 / RL21_HUMAN
Protein Name Large ribosomal subunit protein eL21
Gene Name Name: RPL21
Organism Homo sapiens (Human)

PRO ID PR:P46778
DAG View
PRO Name 60S ribosomal protein L21 (human)
Definition A 60S ribosomal protein L21 that is encoded in the genome of human.
Short Label hRPL21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46778 (RPL21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation PhosphoSitePlus
R17 Methylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
Y30 Phosphorylation PhosphoSitePlus
R32 Methylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K43 Sumoylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
C56 Methylation IEDB 31844290
Y65 Phosphorylation PhosphoSitePlus
N66 N-Glycosylation GlyGen 24190977
T68 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S104 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
K107 Methylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K129 Sumoylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
R136 Methylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T29 I29 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y30 F30 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R32 Q32 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K36 T36 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K50 R50 Biomuta DOID:1324 / lung cancer [ cosmic ]
K50 Q50 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K122 T122 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R136 I136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T143 N143 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]