iPTMnet Report for P46019 (PHKA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46019 / KPB2_HUMAN
Protein Name Phosphorylase b kinase regulatory subunit alpha, liver isoform
Gene Name Name: PHKA2
Synonyms:PHKLA,PYK;
Organism Homo sapiens (Human)

PRO ID PR:P46019
DAG View
PRO Name phosphorylase b kinase regulatory subunit alpha, liver isoform (human)
Definition A phosphorylase b kinase regulatory subunit alpha, liver isoform that is encoded in the genome of human.
Short Label hPHKA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46019 (PHKA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
T617 Phosphorylation PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus   UniProt 23186163
K707 Ubiquitination PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
S729 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18691976, 23186163, ...19369195, 24275569, 19690332, 20068231
S735 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231, ...16565220
K742 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
Y811 Phosphorylation PhosphoSitePlus
K962 Ubiquitination PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
T977 Phosphorylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
T981 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1011 Phosphorylation PhosphoSitePlus
S1015 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 20058876, ...18669648, 19690332
S1022 Phosphorylation PhosphoSitePlus
T1041 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1044 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1046 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 F7 Biomuta DOID:4159 / skin cancer [ cosmic ]
K379 N379 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K485 Q485 Biomuta DOID:1324 / lung cancer [ cosmic ]
S508 C508 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y613 * Biomuta DOID:1612 / breast cancer [ cosmic ]
T717 I717 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K742 R742 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S771 L771 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S978 F978 Biomuta DOID:363 / uterine cancer [ icgc ]
S983 Y983 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1015 N1015 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]