iPTMnet Report for P45974 (USP5)
Protein Information
UniProt AC / UniProt ID | P45974 / UBP5_HUMAN |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 5 |
Gene Name | Name: USP5 Synonyms:ISOT; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P45974 |
PRO Name | ubiquitin carboxyl-terminal hydrolase 5 (human) |
Definition | A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human. |
Short Label | hUSP5 |
Category | organism-gene |
P45974 (USP5) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 22814378, 22223895 | ||
S5 | Phosphorylation | score1 | PhosphoSitePlus | |||
K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
K27 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y57 | Phosphorylation | score1 | PhosphoSitePlus | |||
K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
T65 | Phosphorylation | score1 | PhosphoSitePlus | |||
K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
K121 | Sumoylation | score1 | PhosphoSitePlus | |||
Y128 | Phosphorylation | score1 | PhosphoSitePlus | |||
S156 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S159 | Phosphorylation | score1 | PhosphoSitePlus | |||
K163 | Acetylation | score1 | PhosphoSitePlus | |||
K163 | Sumoylation | score1 | PhosphoSitePlus | |||
K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
K178 | Acetylation | score1 | PhosphoSitePlus | |||
K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
K184 | Acetylation | score1 | PhosphoSitePlus | |||
K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
T213 | Phosphorylation | score1 | PhosphoSitePlus | |||
S216 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y223 | Phosphorylation | score1 | PhosphoSitePlus | |||
K247 | Ubiquitination | score1 | PhosphoSitePlus | |||
T289 | Phosphorylation | score1 | PhosphoSitePlus | |||
K291 | Ubiquitination | score1 | PhosphoSitePlus | |||
T292 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
K353 | Acetylation | score1 | PhosphoSitePlus | |||
K353 | Ubiquitination | score1 | PhosphoSitePlus | |||
K357 | Acetylation | score1 | PhosphoSitePlus | |||
K357 | Ubiquitination | score1 | PhosphoSitePlus | |||
K360 | Sumoylation | score1 | PhosphoSitePlus | |||
K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
K379 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y389 | Phosphorylation | score1 | PhosphoSitePlus | |||
K391 | Ubiquitination | score1 | PhosphoSitePlus | |||
K406 | Ubiquitination | score1 | PhosphoSitePlus | |||
K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
K423 | Ubiquitination | score1 | PhosphoSitePlus | |||
S453 | Phosphorylation | score1 | PhosphoSitePlus | |||
K468 | Ubiquitination | score1 | PhosphoSitePlus | |||
K470 | Ubiquitination | score1 | PhosphoSitePlus | |||
K476 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y479 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y485 | Phosphorylation | score1 | PhosphoSitePlus | |||
K499 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y505 | Phosphorylation | score1 | PhosphoSitePlus | |||
K508 | Ubiquitination | score1 | PhosphoSitePlus | |||
K516 | Ubiquitination | score1 | PhosphoSitePlus | |||
C532 | Methylation | score1 | IEDB | 31844290 | ||
K553 | Ubiquitination | score1 | PhosphoSitePlus | |||
K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
T559 | Phosphorylation | score1 | PhosphoSitePlus | |||
K574 | Ubiquitination | score1 | PhosphoSitePlus | |||
K575 | Ubiquitination | score1 | PhosphoSitePlus | |||
K585 | Ubiquitination | score1 | PhosphoSitePlus | |||
K586 | Ubiquitination | score1 | PhosphoSitePlus | |||
T623 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16964243 | ||
S658 | Phosphorylation | score1 | PhosphoSitePlus | |||
K743 | Ubiquitination | score1 | PhosphoSitePlus | |||
S779 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S783 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 19690332, ... | ||
S785 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S787 | Phosphorylation | score1 | PhosphoSitePlus | |||
K793 | Ubiquitination | score1 | PhosphoSitePlus | |||
K836 | Ubiquitination | score1 | PhosphoSitePlus | |||
K842 | Ubiquitination | score1 | PhosphoSitePlus | |||
K845 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S161 | Phosphorylation | score0 | HPRD | 20068231 | ||
T213 | Phosphorylation | score0 | HPRD | 20068231 | ||
S216 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y485 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y505 | Phosphorylation | score0 | HPRD | 20068231 | ||
T623 | Phosphorylation | score0 | HPRD | 18510355, 16964243 | ||
S779 | Phosphorylation | score0 | HPRD | 20068231 | ||
S783 | Phosphorylation | score0 | HPRD | 18212344, 18767875, 20058876, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S161 | Phosphorylation | score0 | HPRD | 20068231 | ||
T213 | Phosphorylation | score0 | HPRD | 20068231 | ||
S216 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y485 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y505 | Phosphorylation | score0 | HPRD | 20068231 | ||
T623 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18510355, 16964243 | ||
S635 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
S756 | Phosphorylation | score0 | HPRD | 20068231 | ||
S760 | Phosphorylation | score0 | HPRD | 18212344, 18767875, 20058876, ... |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S5 | T5 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S5 | G5 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K80 | R80 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K80 | E80 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S182 | N182 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K247 | T247 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K291 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
K291 | N291 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K379 | T379 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S453 | N453 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y479 | N479 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K575 | N575 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S785 | A785 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S787 | P787 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
S787 | F787 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] |