iPTMnet Report for P43699 (NKX2-1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43699 / NKX21_HUMAN
Protein Name Homeobox protein Nkx-2.1
Gene Name Name: NKX2-1
Synonyms:NKX2A,TITF1,TTF1;
Organism Homo sapiens (Human)

PRO ID PR:P43699
DAG View
PRO Name homeobox protein Nkx-2.1 (human)
Definition A homeobox protein Nkx-2.1 that is encoded in the genome of human.
Short Label hNKX2-1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43699 (NKX2-1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation neXtProt 9211870
T9 Phosphorylation P22694 (PRKACB) neXtProt 9211870
S23 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
R121 Methylation PhosphoSitePlus
R127 Methylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S327 Phosphorylation RLIMS-P 31452510
Site PTM Type PTM Enzyme Score Source PMID
R10 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R10 Q10 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R10 W10 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ]
R127 S127 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K151 E151 Biomuta [ cosmic ]
K184 N184 Biomuta DOID:11615 / penile cancer [ cosmic ]
S254 L254 Biomuta DOID:9256 / colorectal cancer [ icgc ]