iPTMnet Report for P43686 (PSMC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43686 / PRS6B_HUMAN
Protein Name 26S proteasome regulatory subunit 6B
Gene Name Name: PSMC4
Synonyms:MIP224,TBP7;
Organism Homo sapiens (Human)

PRO ID PR:P43686
DAG View
PRO Name 26S proteasome regulatory subunit 6B (human)
Definition A 26S proteasome regulatory subunit 6B that is encoded in the genome of human.
Short Label hPSMC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43686 (PSMC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
S21 Phosphorylation PhosphoSitePlus   UniProt 19690332
T25 Phosphorylation Q92630 (DYRK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 26655835, 24275569
S28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17323924, 18669648, ...19690332, 20068231
Y41 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K134 Methylation PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
R283 Methylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
R338 Methylation PhosphoSitePlus
S346 O-Glycosylation GlyGen 35008409, 30444036, 34725712, ...34229054, 34019948, 28510447, 33465208
S346 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
S350 O-Glycosylation GlyGen 33465208
S350 Phosphorylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus   UniProt 19608861
K397 Ubiquitination PhosphoSitePlus
K401 Acetylation PhosphoSitePlus   UniProt 19608861
K401 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K409 Acetylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation HPRD 18669648
S28 Phosphorylation HPRD 18691976, 18669648, 20068231
S117 Phosphorylation HPRD 20068231
Y164 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation HPRD 18669648
S28 Phosphorylation HPRD 18691976, 18669648, 20068231
S86 Phosphorylation HPRD 20068231
Y133 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K66 T66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K66 N66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K70 N70 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K192 R192 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K273 Q273 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T316 S316 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R338 C338 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R338 H338 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K408 T408 Biomuta DOID:3571 / liver cancer [ cosmic ]