iPTMnet Report for P43405 (SYK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43405 / KSYK_HUMAN
Protein Name Tyrosine-protein kinase SYK
Gene Name Name: SYK
Organism Homo sapiens (Human)

PRO ID PR:P43405
DAG View
PRO Name tyrosine-protein kinase SYK (human)
Definition A tyrosine-protein kinase SYK that is encoded in the genome of human.
Short Label hSYK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43405 (SYK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Y28 Phosphorylation PhosphoSitePlus   UniProt 21469132, 19690332
S44 Phosphorylation UniProt 21469132
Y47 Phosphorylation PhosphoSitePlus   UniProt 21469132
K60 Ubiquitination PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
T117 O-Glycosylation GlyGen 29485866, 30379171
K124 Ubiquitination PhosphoSitePlus
Y131 Phosphorylation P43405 (SYK) PRO   Signor   UniProt 9820500, 21469132
T161 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S178 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 22848421
S202 Phosphorylation PhosphoSitePlus   UniProt 21469132
Y203 Phosphorylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus   UniProt 21469132
K261 Ubiquitination PhosphoSitePlus
S291 Phosphorylation Q15139 (PRKD1) neXtProt   RLIMS-P 20956537, 31881809, 8885868
S295 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   Signor   UniProt 22585575, 21469132
Y296 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 21469132
S297 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 31881809, 21469132, ...33255747
S316 Phosphorylation PhosphoSitePlus   UniProt 21469132
T317 Phosphorylation UniProt 21469132
S319 Phosphorylation PhosphoSitePlus   UniProt 21469132
Y323 Phosphorylation P07948 (LYN) , P43405 (SYK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 14871838, 26315286, ...20670933, 32678160, 28054556, 26584182, 9820500, 21394647, 21469132, 18083107, 23960082, 30744170, 16497976, 27614019, 28105029, 33488575
K334 Ubiquitination PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus   UniProt 21469132
Y348 Phosphorylation P07948 (LYN) , P43405 (SYK) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21352196, 28054556, 18083107, ...9820500, 8657103, 21469132, 14871838, 25612940, 12522270, 18818202, 9151714
S350 Phosphorylation PhosphoSitePlus   UniProt 21469132
Y352 Phosphorylation P43405 (SYK) , P07948 (LYN) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22581261, 19296913, 33435587, ...21469132, 23960082, 17942891, 12522270, 27614019, 33488575, 22693567, 31616406, 23087912, 18068154, 14871838, 30744170, 25858425, 18818202, 18715989, 28105029, 33615197, 27297662, 19092849, 32678160, 9820500, 31519182, 19850008, 27888629, 27258042, 28036404, 32587248, 33159047, 20670933, 21394647, 18083107, 8657103
Y364 Phosphorylation UniProt 21469132
K368 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S379 Phosphorylation UniProt 21469132
T384 Phosphorylation PhosphoSitePlus   UniProt 21469132
K386 Ubiquitination PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation UniProt 21469132
T504 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus   UniProt 21469132
K509 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
Y525 Phosphorylation P43405 (SYK) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28674449, 32977621, 33435587, ...31449558, 28054556, 22669259, 21469132, 23960082, 18362147, 33488575, 30135222, 32768227, 20585042, 28088788, 30460241, 31367693, 24122028, 30744170, 18818202, 31992353, 18715989, 9820500, 33615197, 8798676, 26584182, 25644261, 21394647, 11380624, 32005797, 27888629, 26848618, 26756335, 36166754, 31519182, 31139177, 8657103, 33328565
Y526 Phosphorylation P43405 (SYK) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28674449, 33435587, 31449558, ...32005797, 22669259, 21469132, 23960082, 18362147, 33488575, 30135222, 32768227, 20585042, 30460241, 25644261, 18818202, 31992353, 36166754, 33615197, 8798676, 9820500, 31519182, 11380624, 31139177, 26848618, 26756335, 18083107, 8657103, 33328565
K527 Ubiquitination PhosphoSitePlus
T530 Phosphorylation PhosphoSitePlus   UniProt 21469132
Y539 Phosphorylation PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
K571 Acetylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus   UniProt 21469132
T582 Phosphorylation UniProt 21469132
K587 Ubiquitination PhosphoSitePlus
Y629 Phosphorylation PhosphoSitePlus   UniProt 21469132
Y630 Phosphorylation IntAct   PhosphoSitePlus   UniProt 21469132, 18369315
Y631 Phosphorylation PhosphoSitePlus   UniProt 21469132
Site PTM Type PTM Enzyme Score Source PMID
Y131 Phosphorylation P07948 (LYN) , P43405 (SYK) HPRD 9820500
Y296 Phosphorylation HPRD 18083107
S297 Phosphorylation HPRD 18088087
Y323 Phosphorylation P43405 (SYK) HPRD 17016520, 9857068, 17389395, ...20058876, 16497976
Y348 Phosphorylation P43405 (SYK) HPRD 8657103, 16497976
Y352 Phosphorylation P43405 (SYK) HPRD 8657103, 16497976
Y525 Phosphorylation P43405 (SYK) HPRD 8657103
Y526 Phosphorylation P43405 (SYK) HPRD 8657103
Y568 Phosphorylation HPRD 18083107


P43405 (SYK) as PTM Enzyme



Substrate Site Score Source PMID
O14986 (PIP5K1B) Y105 neXtProt   PhosphoSitePlus 19553680
O43914-2 (TYROBP) Y90 HPRD 9490415
O43914 (TYROBP) Y91 HPRD   phospho.ELM 9490415
O43914-2 (TYROBP) Y101 HPRD 9490415
O43914-1 (TYROBP) Y102 HPRD   phospho.ELM 9490415
P02730 (SLC4A1) Y8 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10942405, 2065070, 1998697, ...17404032
P02730 (SLC4A1) Y21 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10942405, 2065070, 1998697, ...17404032
P02730 (SLC4A1) Y359 HPRD   phospho.ELM   PhosphoSitePlus 10942405, 2065070, 17404032
P02730 (SLC4A1) Y904 HPRD   phospho.ELM   PhosphoSitePlus 10942405, 2065070, 17404032
P05106 (ITGB3) Y785 phospho.ELM 8631894
P05771 (PRKCB) Y662 neXtProt 12881490
P06239 (LCK) Y192 HPRD   RLIMS-P+   Signor 7518561, 19664994, 8798764, ...16497976
P10636 (MAPT) Y18 neXtProt   PhosphoSitePlus   Signor 18070606
P11912 (CD79A) S197 RLIMS-P+ 20940318
P11912 (CD79A) S203 neXtProt 20940318, 7538118
P12318-2 (FCGR2A) Y280 HPRD 8756631
P12318 (FCGR2A) Y281 neXtProt   phospho.ELM   PhosphoSitePlus 8756631
P12318-2 (FCGR2A) Y287 HPRD 8756631
P12318 (FCGR2A) Y288 phospho.ELM 8756631
P12318-2 (FCGR2A) Y303 HPRD 8756631
P12318 (FCGR2A) Y304 neXtProt   phospho.ELM   PhosphoSitePlus 8756631
P13569 (CFTR) Y512 neXtProt   PhosphoSitePlus 21807898, 21930781
P14317 (HCLS1) Y378 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16782030, 9104825
P14317 (HCLS1) Y397 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16782030, 9104825
P15498 (VAV1) Y174 neXtProt 8986718, 21606197
P16885 (PLCG2) Y759 neXtProt   PhosphoSitePlus 14656219
P17252 (PRKCA) Y658 HPRD   neXtProt   phospho.ELM   Signor 12881490, 20068231
P19174 (PLCG1) Y771 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
P19174 (PLCG1) Y783 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
P22681 (CBL) Y700 neXtProt   phospho.ELM   PhosphoSitePlus 9535867, 9525940
P22681 (CBL) Y731 neXtProt   phospho.ELM   PhosphoSitePlus 9535867, 9525940
P22681 (CBL) Y774 neXtProt   phospho.ELM   PhosphoSitePlus 9535867, 9525940
P25963 (NFKBIA) Y42 RLIMS-P+ 24101387
P29353-2 (SHC1) Y239 HPRD   PhosphoSitePlus 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
P29353-2 (SHC1) Y240 HPRD   PhosphoSitePlus 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
P29353-2 (SHC1) Y317 PhosphoSitePlus 9710204
P29353-1 (SHC1) Y349 HPRD   phospho.ELM   Signor 17016520, 19901323, 17389395, ...9710204, 15688026, 16497976, 20068231, 9685404
P29353 (SHC1) Y350 HPRD   phospho.ELM   Signor 19901323, 17389395, 9710204, ...15688026, 9685404, 20068231, 16497976
P29353 (SHC1) Y427 phospho.ELM   Signor 9710204
P30307 (CDC25C) S216 RLIMS-P+ 25506060
P31995 (FCGR2C) Y287 neXtProt   phospho.ELM   PhosphoSitePlus 8756631
P31995 (FCGR2C) Y310 neXtProt   PhosphoSitePlus 8756631
P37840-2 (SNCA) Y108 HPRD 11744621
P37840 (SNCA) Y125 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12096713, 11162638, 11744621
P37840-1 (SNCA) Y133 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11744621
P37840 (SNCA) Y136 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11744621
P42229 (STAT5A) Y694 PhosphoSitePlus 10849428
P43405 (SYK) Y131 HPRD   Signor 9820500
P43405 (SYK) Y323 HPRD   Signor 17016520, 17389395, 20058876, ...9820500, 9857068, 16497976
P43405 (SYK) Y348 HPRD   phospho.ELM   PhosphoSitePlus   Signor 9820500, 18818202, 8657103, ...16497976
P43405 (SYK) Y352 HPRD   phospho.ELM   PhosphoSitePlus   Signor 9820500, 18818202, 8657103, ...16497976
P43405-1 (SYK) Y525 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9820500, 18818202, 8657103, ...21469132, 11380624
P43405 (SYK) Y526 HPRD   phospho.ELM   PhosphoSitePlus   Signor 9820500, 18818202, 8657103, ...11380624
P51452 (DUSP3) Y38 PhosphoSitePlus 12447358
P51452 (DUSP3) Y138 phospho.ELM   PhosphoSitePlus 12447358
P52566 (ARHGDIB) Y24 PhosphoSitePlus 24055812
P68366-1 (TUBA4A) Y432 HPRD   Signor 9490415, 8617742
P78314-1 (SH3BP2) Y174 HPRD   neXtProt 12709437
P78314-1 (SH3BP2) Y183 HPRD   neXtProt 12709437, 11390470
P78314 (SH3BP2) Y448 HPRD   neXtProt 12709437
Q06187 (BTK) Y551 HPRD   neXtProt   PhosphoSitePlus   Signor 11598012, 8630736, 11226282, ...8629002
Q13094 (LCP2) Y113 neXtProt   phospho.ELM   PhosphoSitePlus 15388330, 8702662, 22267732
Q13094 (LCP2) Y128 neXtProt   phospho.ELM   PhosphoSitePlus 15388330, 8702662, 22267732
Q13261 (IL15RA) Y227 HPRD   Signor 11714793
Q13422 (IKZF1) S361 PhosphoSitePlus   Signor 23071339
Q13422 (IKZF1) S364 PhosphoSitePlus   Signor 23071339
Q14289 (PTK2B) Y402 phospho.ELM 8816475
Q8IWV1 (LAX1) Y193 Signor 12359715
Q8IWV1 (LAX1) Y268 Signor 12359715
Q8IWV1 (LAX1) Y294 Signor 12359715
Q8IWV1 (LAX1) Y373 Signor 12359715
Q8N6F7 (GCSAM) Y107 PhosphoSitePlus 17489982
Q8N6F7 (GCSAM) Y128 PhosphoSitePlus 17489982
Q8WV28 (BLNK) Y72 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12456653, 9697839
Q8WV28 (BLNK) Y84 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12456653, 9697839
Q8WV28 (BLNK) Y96 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12456653, 9697839
Q8WV28 (BLNK) Y178 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12456653, 9697839
Q8WV28 (BLNK) Y189 neXtProt   PhosphoSitePlus 12456653, 9697839
Q92918 (MAP4K1) Y381 HPRD   phospho.ELM   Signor 11514608
Q9GZY6 (LAT2) Y136 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y193 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y233 PhosphoSitePlus 17993265
Q9ULZ3 (PYCARD) Y146 RLIMS-P+ 25605870
Q9ULZ3 (PYCARD) Y187 RLIMS-P+ 25605870


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026221 (hSYK/Phos:2) pY348 PRO
PR:000049391 (hSYK/Phos:3) pY131,pY323,pY348,pY352,pY525,pY526 PRO
PR:000049392 (hSYK/PhosTyr+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P43405 (SYK) Y323 P22681 (CBL) unknown eFIP 27614019


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y28 D28 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S44 I44 Biomuta DOID:3571 / liver cancer [ cosmic ]
S44 G44 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y47 N47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y91 C91 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K105 E105 Biomuta DOID:1324 / lung cancer [ cosmic ]
K105 N105 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K261 R261 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S291 P291 Biomuta DOID:11615 / penile cancer [ cosmic ]
S291 L291 Biomuta DOID:4159 / skin cancer [ cosmic ]
S291 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S295 L295 Biomuta DOID:1612 / breast cancer [ cosmic ]
S297 C297 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S297 F297 Biomuta DOID:4159 / skin cancer [ cosmic ]
S316 N316 Biomuta DOID:1319 / brain cancer [ cosmic ]
S316 G316 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S316 C316 Biomuta DOID:1324 / lung cancer [ cosmic ]
T345 R345 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y348 S348 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y348 H348 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y348 N348 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y348 C348 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y348 D348 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K375 N375 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S379 F379 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y431 C431 Biomuta DOID:363 / uterine cancer [ icgc ]
K509 R509 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K527 N527 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
Y539 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y539 C539 Biomuta DOID:363 / uterine cancer [ icgc ]
Y539 N539 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y568 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y568 H568 Biomuta DOID:1324 / lung cancer [ cosmic ]
T582 A582 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]