iPTMnet Report for P43354 (NR4A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43354 / NR4A2_HUMAN
Protein Name Nuclear receptor subfamily 4 group A member 2
Gene Name Name: NR4A2
Synonyms:NOT,NURR1,TINUR;
Organism Homo sapiens (Human)

PRO ID PR:P43354
DAG View
PRO Name nuclear receptor subfamily 4 group A member 2 (human)
Definition A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human.
Short Label hNR4A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43354 (NR4A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y71 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24223135, 17681692
T129 Phosphorylation PhosphoSitePlus
T132 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17681692
S177 Phosphorylation PhosphoSitePlus
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 24223135, 17081983
T185 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S337 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 21979916
S347 Phosphorylation PhosphoSitePlus   RLIMS-P 19522012
S351 Phosphorylation PhosphoSitePlus
S356 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S359 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S363 Phosphorylation PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
K558 Sumoylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K577 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S181 Phosphorylation HPRD 17081983
S347 Phosphorylation Q15418 (RPS6KA1) HPRD 16223362
S356 Phosphorylation HPRD 18669648
S359 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S126 L126 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
T129 M129 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S181 L181 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T185 I185 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y275 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
Y275 H275 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T279 I279 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S347 L347 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S356 F356 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S359 L359 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]