iPTMnet Report for P42685 (FRK)
Protein Information
| UniProt AC / UniProt ID | P42685 / FRK_HUMAN |
| Protein Name | Tyrosine-protein kinase FRK |
| Gene Name | Name: FRK Synonyms:PTK5,RAK; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P42685 |
| PRO Name | tyrosine-protein kinase FRK (human) |
| Definition | A tyrosine-protein kinase FRK that is encoded in the genome of human. |
| Short Label | hFRK |
| Category | organism-gene |
DAG ViewP42685 (FRK) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S37 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976 | ||
| S40 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| Y46 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| Y53 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T57 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S92 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S93 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y99 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y104 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y132 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S133 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S139 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T178 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y193 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y221 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S233 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y303 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y317 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y368 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y387 | Phosphorylation | P42685 (FRK) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P | 18083107, 29348886, 15186217 | |
| S389 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T400 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S407 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K409 | Acetylation | score1 | PhosphoSitePlus | |||
| S495 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S496 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y497 | Phosphorylation | P41240 (CSK) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 18083107, 7696183, 15951569 | |
| S498 | Phosphorylation | score1 | PhosphoSitePlus |
P42685 (FRK) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P38398 (BRCA1) | Y1552 | score2 | PhosphoSitePlus | 26513018 | |
| P42685 (FRK) | Y387 | score2 | neXtProt | 15186217 | |
| P60484 (PTEN) | Y336 | score3 | neXtProt PhosphoSitePlus | 19345329 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S62 | G62 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S92 | T92 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S93 | G93 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y99 | N99 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S102 | Y102 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S102 | C102 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S139 | F139 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T178 | M178 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S184 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y193 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S389 | F389 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| K409 | E409 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S496 | L496 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| S498 | L498 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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