iPTMnet Report for P42680 (TEC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42680 / TEC_HUMAN
Protein Name Tyrosine-protein kinase Tec
Gene Name Name: TEC
Synonyms:PSCTK4;
Organism Homo sapiens (Human)

PRO ID PR:P42680
DAG View
PRO Name tyrosine-protein kinase Tec (human)
Definition A tyrosine-protein kinase Tec that is encoded in the genome of human.
Short Label hTEC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42680 (TEC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
Y206 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 19369195, 12573241
Y206 Phosphorylation P42680 (TEC) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12573241
Y206 Phosphorylation Q06187 (BTK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12573241
Y206 Phosphorylation Q08881 (ITK) phospho.ELM   PhosphoSitePlus   Signor 12573241
Y223 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y233 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
Y343 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation neXtProt   PRO   PhosphoSitePlus   UniProt 19690332, 9473212
Y519 Phosphorylation O60674 (JAK2) neXtProt 9473212
Y519 Phosphorylation P07948 (LYN) neXtProt 9473212
Y519 Phosphorylation P42680 (TEC) UniProt 19690332
T520 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus


P42680 (TEC) as PTM Enzyme



Substrate Site Score Source PMID
P09038 (FGF2) Y215 neXtProt 20230531
P09038 (FGF2) Y257 neXtProt 20230531
P16885 (PLCG2) Y753 neXtProt 15184383
P16885 (PLCG2) Y759 neXtProt 15184383
P42680 (TEC) Y206 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12573241
P42680 (TEC) Y519 UniProt 19690332
P51813 (BMX) Y216 HPRD   PhosphoSitePlus   Signor 12573241
P51813 (BMX) Y224 HPRD   phospho.ELM   Signor 12573241
Q06187 (BTK) Y223 HPRD   PhosphoSitePlus   Signor 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Q08881 (ITK) Y180 PhosphoSitePlus 12573241
Q13322 (GRB10) Y67 neXtProt 9753425
Q99952 (PTPN18) Y281 HPRD   PhosphoSitePlus 14679216
Q99952 (PTPN18) Y303 HPRD   PhosphoSitePlus 14679216
Q99952-1 (PTPN18) Y354 HPRD   PhosphoSitePlus 14679216
Q99952 (PTPN18) Y389 PhosphoSitePlus 14679216


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049416 (hTEC/Phos:1) pY206,pY519 PRO
PR:000049417 (hTEC/Phos:2) pY519 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K60 T60 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y360 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y519 C519 Biomuta DOID:10534 / stomach cancer [ cosmic ]