iPTMnet Report for P42338 (PIK3CB)
Protein Information
| UniProt AC / UniProt ID | P42338 / PK3CB_HUMAN |
| Protein Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| Gene Name | Name: PIK3CB Synonyms:PIK3C1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P42338 |
| PRO Name | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (human) |
| Definition | A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human. |
| Short Label | hPIK3CB |
| Category | organism-gene |
DAG ViewP42338 (PIK3CB) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T113 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S115 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K125 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K159 | Acetylation | score1 | PhosphoSitePlus | |||
| S167 | Phosphorylation | score1 | IEDB | 30784271 | ||
| K173 | Acetylation | score1 | PhosphoSitePlus | |||
| K191 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K230 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y244 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S416 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T417 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S423 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y425 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y436 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y503 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y504 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y505 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K514 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S520 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K711 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T721 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S724 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K732 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K747 | Methylation | score1 | PhosphoSitePlus | |||
| Y772 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16497976 | ||
| K828 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K886 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S947 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K952 | Sumoylation | score1 | PhosphoSitePlus | |||
| T961 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y962 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1025 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1032 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1039 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1044 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1070 | Phosphorylation | P42338 (PIK3CB) | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt | 12661022, 12502714 |
P42338 (PIK3CB) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P42338 (PIK3CB) | S1070 | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 12661022, 12502714 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K141 | T141 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K159 | R159 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| Y244 | H244 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] | |
| S416 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T417 | M417 | Biomuta | DOID:184 / bone cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y504 | N504 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| Y962 | N962 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] | |
| Y962 | C962 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] | |
| Y962 | S962 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K1025 | E1025 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
| S1070 | Y1070 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] |
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