iPTMnet Report for P42226 (STAT6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42226 / STAT6_HUMAN
Protein Name Signal transducer and activator of transcription 6
Gene Name Name: STAT6
Organism Homo sapiens (Human)

PRO ID PR:P42226
DAG View
PRO Name signal transducer and activator of transcription 6 (human)
Definition A signal transducer and activator of transcription 6 that is encoded in the genome of human.
Short Label hSTAT6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42226 (STAT6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S2 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
C384 Methylation IEDB 31844290
S407 Phosphorylation Q9UHD2 (TBK1) PRO   PhosphoSitePlus   Signor 22000020
K450 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
T525 Phosphorylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
Y641 Phosphorylation Q9UHD2 (TBK1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26951976, 28430601, 30532138, ...12093868, 26758199, 27317770, 26208975, 22142941, 22000020, 29771943, 11944890, 23845085, 20668749, 15069079, 16181056, 27796300, 19367337, 10961885, 29485045, 18494930, 25428220, 28414040, 28099521
T645 Phosphorylation phospho.ELM   PhosphoSitePlus 15069079
K647 Ubiquitination PhosphoSitePlus
S707 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21123173
S756 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 15069079, 15523052
S817 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 20068231
Y641 Phosphorylation HPRD 11944890


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049366 (hSTAT6/Phos:2) pS407 PRO
PR:000049367 (hSTAT6/Phos:3) pS407,pY641 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K284 N284 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K319 R319 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K621 R621 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K636 N636 Biomuta DOID:363 / uterine cancer [ icgc ]
T645 I645 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S707 P707 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]