Protein Information

Cytoscape View


UniProt AC / UniProt ID P41181 / AQP2_HUMAN
Protein Name Aquaporin-2
Gene Name Name: AQP2
Organism Homo sapiens (Human)

PRO ID PR:P41181
DAG View
PRO Name aquaporin-2 (human)
Definition An aquaporin-2 that is encoded in the genome of human.
Short Label hAQP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41181 (AQP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K228 Ubiquitination PhosphoSitePlus
S256 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17138647, 29650969, 23559583, ...16120822, 17940053, 28630457, 12897058, 29799470, 28326667, 22778181, 32486031, 24829494, 19570884, 18678705, 16303856, 17116290, 18606813, 12194985, 18042467, 31888044, 19585583, 24876223, 18434387, 28710278, 27801846, 18695390, 32529500, 29145196, 10710543, 11076974, 20187088, 20971851
S256 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 18042467
S261 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 32164329, 28381458, 28931009, ...22778181, 29145196, 18434387, 28710278, 28108651, 20971851
S261 Phosphorylation Q07002 (CDK18) Signor 32164329
S264 Phosphorylation PhosphoSitePlus   RLIMS-P 28710278, 22778181
T269 Phosphorylation PhosphoSitePlus   RLIMS-P 32486031, 29145196, 22778181, ...28710278
K270 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K228 E228 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S264 I264 Biomuta DOID:3571 / liver cancer [ cosmic ]