iPTMnet Report for P41180 (CASR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P41180 / CASR_HUMAN
Protein Name Extracellular calcium-sensing receptor precursor
Gene Name Name: CASR
Synonyms:GPRC2A,PCAR1;
Organism Homo sapiens (Human)

PRO ID PR:P41180
DAG View
PRO Name extracellular calcium-sensing receptor (human)
Definition An extracellular calcium-sensing receptor that is encoded in the genome of human.
Short Label hCASR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41180 (CASR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T186 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
N261 N-Glycosylation GlyGen   UniProt 27434672
N287 N-Glycosylation GlyGen   UniProt 27434672
K336 Acetylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
N446 N-Glycosylation GlyGen   UniProt 29741879, 27434672
N468 N-Glycosylation GlyGen   UniProt 27434672
N488 N-Glycosylation GlyGen   UniProt 27434672
N541 N-Glycosylation GlyGen   UniProt 27434672
N594 N-Glycosylation GlyGen   UniProt 27434672
S875 Phosphorylation PhosphoSitePlus
T888 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24336654, 17376781, 12409307, ...9694886, 21135065, 12356761
T888 Phosphorylation P05771 (PRKCB) Signor 12356761
T888 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 9694886, 12409307, 17376781, ...21135065
S892 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
S900 Phosphorylation PhosphoSitePlus
T906 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T888 Phosphorylation HPRD 9694886, 12356761
T888 Phosphorylation P05129 (PRKCG) HPRD 9694886
T888 Phosphorylation P05771 (PRKCB) HPRD 9694886, 12356761
T888 Phosphorylation P17252 (PRKCA) HPRD 9694886


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T186 I186 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S342 F342 Biomuta DOID:4159 / skin cancer [ cosmic ]
N468 S468 Biomuta DOID:1612 / breast cancer [ cosmic ]
S875 R875 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S875 T875 Biomuta DOID:1319 / brain cancer [ cosmic ]
T888 M888 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T906 A906 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S915 I915 Biomuta DOID:1612 / breast cancer [ cosmic ]