iPTMnet Report for P39748 (FEN1)
Protein Information
UniProt AC / UniProt ID | P39748 / FEN1_HUMAN |
Protein Name | Flap endonuclease 1 |
Gene Name | Name: FEN1 Synonyms:RAD2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P39748 |
PRO Name | flap endonuclease 1 (human) |
Definition | A flap endonuclease 1 that is encoded in the genome of human. |
Short Label | hFEN1 |
Category | organism-gene |
P39748 (FEN1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K8 | Ubiquitination | score1 | PhosphoSitePlus | |||
S16 | Phosphorylation | score1 | PhosphoSitePlus | |||
R19 | Methylation | score1 | PhosphoSitePlus | |||
K24 | Sumoylation | score1 | PhosphoSitePlus | |||
K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
M67 | Methylation | score1 | IEDB | 25880248 | ||
K80 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
K88 | Sumoylation | score1 | PhosphoSitePlus | |||
K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
K93 | Sumoylation | score1 | PhosphoSitePlus | |||
K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
R100 | Methylation | score1 | PhosphoSitePlus | |||
S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
R104 | Methylation | score1 | PhosphoSitePlus | |||
K109 | Acetylation | score1 | PhosphoSitePlus | |||
K109 | Ubiquitination | score1 | PhosphoSitePlus | |||
K125 | Acetylation | score1 | PhosphoSitePlus | |||
K125 | Sumoylation | score1 | PhosphoSitePlus | |||
K125 | Ubiquitination | score1 | PhosphoSitePlus | |||
K128 | Sumoylation | score1 | PhosphoSitePlus | |||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
K135 | Ubiquitination | score1 | PhosphoSitePlus | |||
K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
C163 | Methylation | score1 | IEDB | 31844290 | ||
C163 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K168 | Sumoylation | score1 | PhosphoSitePlus | |||
K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
K171 | Ubiquitination | score1 | PhosphoSitePlus | |||
S187 | Phosphorylation | P06493 (CDK1) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 33770148, 12853968, 20729856 | |
R192 | Methylation | score1 | PhosphoSitePlus | |||
T195 | Phosphorylation | O14757 (CHEK1) | score1 | PhosphoSitePlus | 21851590 | |
S197 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
K200 | Acetylation | score1 | PhosphoSitePlus | |||
K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
K201 | Acetylation | score1 | PhosphoSitePlus | |||
K201 | Sumoylation | score1 | PhosphoSitePlus | |||
K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y234 | Phosphorylation | score1 | PhosphoSitePlus | |||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
K254 | Sumoylation | score1 | PhosphoSitePlus | |||
K254 | Ubiquitination | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K267 | Acetylation | score1 | PhosphoSitePlus | |||
K267 | Sumoylation | score1 | PhosphoSitePlus | |||
K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y268 | Phosphorylation | score1 | PhosphoSitePlus | |||
K277 | Ubiquitination | score1 | PhosphoSitePlus | |||
S293 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K297 | Sumoylation | score1 | PhosphoSitePlus | |||
K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
K308 | Sumoylation | score1 | PhosphoSitePlus | |||
K308 | Ubiquitination | score1 | PhosphoSitePlus | |||
K314 | Sumoylation | score1 | PhosphoSitePlus | |||
K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
S317 | Phosphorylation | score1 | PhosphoSitePlus | |||
S329 | Phosphorylation | score1 | PhosphoSitePlus | |||
S331 | Phosphorylation | score1 | PhosphoSitePlus | |||
S335 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T336 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K345 | Methylation | score1 | PhosphoSitePlus | |||
K345 | Sumoylation | score1 | PhosphoSitePlus | |||
K345 | Ubiquitination | score1 | PhosphoSitePlus | |||
S349 | Phosphorylation | score1 | PhosphoSitePlus | |||
S351 | Phosphorylation | score1 | PhosphoSitePlus | |||
S352 | O-Glycosylation | score2 | GlyGen | 34590401 | ||
S352 | Phosphorylation | score1 | PhosphoSitePlus | |||
K354 | Acetylation | score3 | PhosphoSitePlus UniProt | 11430825 | ||
K354 | Sumoylation | score1 | PhosphoSitePlus | |||
K354 | Ubiquitination | score1 | PhosphoSitePlus | |||
S363 | Phosphorylation | score1 | PhosphoSitePlus | |||
T364 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
K369 | Methylation | score1 | PhosphoSitePlus | |||
K375 | Acetylation | score4 | PhosphoSitePlus UniProt | 11430825, 19608861 | ||
K375 | Sumoylation | score1 | PhosphoSitePlus | |||
K377 | Acetylation | score3 | PhosphoSitePlus UniProt | 11430825 | ||
K377 | Methylation | score1 | PhosphoSitePlus | |||
K380 | Acetylation | score3 | PhosphoSitePlus UniProt | 11430825 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P39748 (FEN1) | S187 | P12004 (PCNA) | unknown | eFIP | 20729856 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R19 | W19 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R100 | C100 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R104 | Q104 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
R192 | Q192 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K254 | N254 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S255 | I255 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
K277 | * | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
S351 | Y351 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |