iPTMnet Report for P38435 (GGCX)
Protein Information
UniProt AC / UniProt ID | P38435 / VKGC_HUMAN |
Protein Name | Vitamin K-dependent gamma-carboxylase |
Gene Name | Name: GGCX Synonyms:GC; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P38435 |
PRO Name | vitamin K-dependent gamma-carboxylase (human) |
Definition | A vitamin K-dependent gamma-carboxylase that is encoded in the genome of human. |
Short Label | hGGCX |
Category | organism-gene |
P38435 (GGCX) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 21406692 | ||
S7 | Phosphorylation | score1 | PhosphoSitePlus | |||
T10 | Phosphorylation | score1 | PhosphoSitePlus | |||
S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
K16 | Ubiquitination | score1 | PhosphoSitePlus | |||
K19 | Acetylation | score1 | PhosphoSitePlus | |||
K19 | Ubiquitination | score1 | PhosphoSitePlus | |||
K21 | Ubiquitination | score1 | PhosphoSitePlus | |||
S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
K91 | Ubiquitination | score1 | PhosphoSitePlus | |||
K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
K334 | Ubiquitination | score1 | PhosphoSitePlus | |||
K346 | Ubiquitination | score1 | PhosphoSitePlus | |||
K351 | Ubiquitination | score1 | PhosphoSitePlus | |||
K438 | Ubiquitination | score1 | PhosphoSitePlus | |||
K445 | Ubiquitination | score1 | PhosphoSitePlus | |||
N459 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
K515 | Ubiquitination | score1 | PhosphoSitePlus | |||
N550 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
N570 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
K578 | Ubiquitination | score1 | PhosphoSitePlus | |||
N627 | N-Glycosylation | score1 | GlyGen | 29741879, 24190977 | ||
T653 | O-Glycosylation | score1 | GlyGen | 33214551, 30459171, 34725712, ... | ||
S695 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S26 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
K91 | N91 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K318 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K445 | R445 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
N459 | D459 | Biomuta | DOID:3565 / meningioma [ cosmic ] |