iPTMnet Report for P37173 (TGFBR2)
Protein Information
| UniProt AC / UniProt ID | P37173 / TGFR2_HUMAN |
| Protein Name | TGF-beta receptor type-2 precursor |
| Gene Name | Name: TGFBR2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P37173 |
| PRO Name | TGF-beta receptor type-2 (human) |
| Definition | A TGF-beta receptor type-2 that is encoded in the genome of human. |
| Short Label | hTGFBR2 |
| Category | organism-gene |
DAG ViewP37173 (TGFBR2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S31 | O-Glycosylation | score1 | PhosphoSitePlus | |||
| T39 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| N70 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N94 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S213 | Phosphorylation | P37173 (TGFBR2) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor | 9155023 | |
| Y259 | Phosphorylation | P37173 (TGFBR2) | score3 | neXtProt phospho.ELM PhosphoSitePlus | 9169454 | |
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N266 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| Y284 | Phosphorylation | P12931 (SRC) | score4 | IntAct neXtProt PhosphoSitePlus RLIMS-P Signor | 17440088, 19114990 | |
| K291 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K300 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y336 | Phosphorylation | P37173 (TGFBR2) | score3 | neXtProt phospho.ELM PhosphoSitePlus | 9169454 | |
| S352 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K381 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S409 | Phosphorylation | P37173 (TGFBR2) | score3 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 9155023 | |
| S416 | Phosphorylation | P37173 (TGFBR2) | score3 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 9155023 | |
| Y424 | Phosphorylation | P37173 (TGFBR2) | score3 | neXtProt phospho.ELM PhosphoSitePlus | 9169454 | |
| T445 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y470 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K477 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S486 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K488 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S548 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 17081983, ... | ||
| S551 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S553 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K556 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S562 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N564 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| T566 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S213 | Phosphorylation | P37173 (TGFBR2) | score3 | HPRD PRO | 9155023 | |
| S225 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S228 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S229 | Phosphorylation | score1 | HPRD | 8947046 | ||
| Y259 | Phosphorylation | score3 | HPRD PRO | 9169454 | ||
| Y336 | Phosphorylation | score3 | HPRD PRO | 9169454 | ||
| S409 | Phosphorylation | P37173 (TGFBR2) | score3 | HPRD PRO | 9155023 | |
| S416 | Phosphorylation | P37173 (TGFBR2) | score1 | HPRD | 9169454 | |
| Y424 | Phosphorylation | score3 | HPRD PRO | 9169454 | ||
| S548 | Phosphorylation | score0 | HPRD | 18691976, 18578522, 17081983 | ||
| S551 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S553 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S562 | Phosphorylation | score0 | HPRD | 18578522 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S31 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S238 | Phosphorylation | P37173 (TGFBR2) | score1 | HPRD | 9155023 | |
| S250 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S253 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S254 | Phosphorylation | score1 | HPRD | 8947046 | ||
| Y284 | Phosphorylation | score1 | HPRD | 9169454 | ||
| Y361 | Phosphorylation | score1 | HPRD | 9169454 | ||
| S434 | Phosphorylation | P37173 (TGFBR2) | score1 | HPRD | 9155023 | |
| S441 | Phosphorylation | P37173 (TGFBR2) | score1 | HPRD | 9169454 | |
| Y449 | Phosphorylation | score1 | HPRD | 9169454 | ||
| S573 | Phosphorylation | score0 | HPRD | 18691976, 18578522, 17081983 | ||
| S576 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S578 | Phosphorylation | score1 | HPRD | 8947046 | ||
| S587 | Phosphorylation | score0 | HPRD | 18578522 |
P37173 (TGFBR2) as PTM Enzyme
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID |
|---|---|---|---|---|
| PR:000025959 (hTGFBR1/iso:1/SigPep-/Phos:1) | pS165,pT185,pT186,pS187,pS189,pS191 | PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1) | PRO | 7774578, 8947046 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1) | pS213,pY259,pY336,pS409,pY424 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O43683 (BUB1) | S318 | P37173 (TGFBR2) | unknown | eFIP | 32143140 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000036408 (hTGFBR2/iso:RII-1/SigPep-) | Interaction | PR:000000616 (TGFB1/iso:1/mature) | PRO | 1310899 | |
| PR:000036408 (hTGFBR2/iso:RII-1/SigPep-) | Interaction | PR:000000634 (TGFB3/iso:1/Clv:1) | PRO | 1850637 |
PTM sites affected in variants
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