iPTMnet Report for P36888 (FLT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P36888 / FLT3_HUMAN
Protein Name Receptor-type tyrosine-protein kinase FLT3 precursor
Gene Name Name: FLT3
Synonyms:CD135,FLK2,STK1;
Organism Homo sapiens (Human)

PRO ID PR:P36888
DAG View
PRO Name receptor-type tyrosine-protein kinase FLT3 (human)
Definition A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.
Short Label hFLT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36888 (FLT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N43 N-Glycosylation GlyGen   UniProt 21389326
N100 N-Glycosylation GlyGen   UniProt 21389326
N151 N-Glycosylation GlyGen   UniProt 21389326
Y166 Phosphorylation PhosphoSitePlus
N306 N-Glycosylation GlyGen   UniProt 21389326
R311 Methylation PhosphoSitePlus
R322 Methylation PhosphoSitePlus
N323 N-Glycosylation GlyGen   UniProt 21389326
T343 Phosphorylation PhosphoSitePlus
N351 N-Glycosylation GlyGen   UniProt 21389326
N354 N-Glycosylation GlyGen   UniProt 21389326
Y416 Phosphorylation PhosphoSitePlus
Y566 Phosphorylation IntAct 27458164
Y572 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   UniProt 16684964, 27458164, 21262971, ...23246379
S574 Phosphorylation neXtProt   UniProt 16684964
Y589 Phosphorylation P36888 (FLT3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19477218, 9737679, 22411868, ...21262971, 16684964, 27458164, 11971190
Y591 Phosphorylation P36888 (FLT3) , P11309 (PIM1) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 24608088, 24040307, 15831474, ...16627759, 25640477, 35339838, 19477218, 22411868, 22952242, 21262971, 31606550, 16684964, 26601252, 27458164, 33363015, 11971190
Y597 Phosphorylation P36888 (FLT3) phospho.ELM   PhosphoSitePlus   Signor 11971190
Y599 Phosphorylation P36888 (FLT3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19477218, 21262971, 16684964, ...27458164, 11971190
K602 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
R655 Methylation PhosphoSitePlus
R707 Methylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
Y726 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28086240, 16627759, 19477218, ...21552520, 27458164
T728 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y768 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   UniProt 19477218, 21262971, 19438505
K772 Ubiquitination PhosphoSitePlus
Y793 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28086240, 23246379, 19477218, ...21262971, 27458164
S840 Phosphorylation PhosphoSitePlus
Y842 Phosphorylation P36888 (FLT3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33391463, 28086240, 16627759, ...19477218, 21262971, 15345593, 21552520
Y919 Phosphorylation IntAct   RLIMS-P 22952242, 27458164, 33363015
K932 Ubiquitination PhosphoSitePlus
S935 Phosphorylation RLIMS-P 26601252
Y955 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   UniProt 19438505, 19477218, 21262971, ...27458164, 16627759
T968 Phosphorylation PhosphoSitePlus
Y969 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31395582, 19438505, 21552520, ...27458164, 16627759
R972 Methylation PhosphoSitePlus
R973 Methylation PhosphoSitePlus
S993 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
Y589 Phosphorylation P36888 (FLT3) HPRD 11971190
Y591 Phosphorylation P36888 (FLT3) HPRD 11971190
Y597 Phosphorylation P36888 (FLT3) HPRD 11971190
Y599 Phosphorylation P36888 (FLT3) HPRD 11971190


P36888 (FLT3) as PTM Enzyme



Substrate Site Score Source PMID
P24752 (ACAT1) Y407 Signor 34289383
P29353-7 (SHC1) Y239 HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
P29353-7 (SHC1) Y240 HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
P29353-7 (SHC1) Y318 HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P29353 (SHC1) Y349 Signor 10482988
P29353 (SHC1) Y350 Signor 10482988
P29353 (SHC1) Y427 Signor 10482988
P35222 (CTNNB1) Y654 RLIMS-P+ 22126602
P36888 (FLT3) Y572 neXtProt 16684964
P36888 (FLT3) Y589 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16684964, 19477218, 9737679, ...22411868, 11971190
P36888 (FLT3) Y591 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15831474, 16627759, 19477218, ...22411868, 16684964, 11971190
P36888-1 (FLT3) Y597 HPRD   phospho.ELM   Signor 11971190
P36888 (FLT3) Y599 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16684964, 19477218, 11971190
P36888 (FLT3) Y726 neXtProt   PhosphoSitePlus   UniProt 19477218, 16627759
P36888 (FLT3) Y768 neXtProt 19477218, 19438505
P36888 (FLT3) Y793 neXtProt 19477218
P36888 (FLT3) Y842 neXtProt   PhosphoSitePlus   UniProt 19477218, 16627759
P36888 (FLT3) Y955 neXtProt   PhosphoSitePlus   UniProt 19477218, 19438505, 16627759
P36888 (FLT3) Y969 neXtProt   PhosphoSitePlus   Signor   UniProt 31395582, 19438505, 16627759
P48735 (IDH2) Y107 Signor 34289383
Q15118 (PDK1) Y243 neXtProt   PhosphoSitePlus 22195962


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y166 * Biomuta DOID:1324 / lung cancer [ cosmic ]
N306 I306 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
N306 H306 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R311 W311 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
R311 Q311 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
R311 P311 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R322 I322 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
N323 K323 Biomuta DOID:1324 / lung cancer [ cosmic ]
N323 S323 Biomuta DOID:4159 / skin cancer [ cosmic ]
N323 H323 Biomuta DOID:363 / uterine cancer [ icgc ]
Y566 N566 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y572 C572 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S574 N574 Biomuta [ cosmic ]
Y589 D589 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y589 H589 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y589 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y591 D591 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y591 H591 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y597 N597 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y597 F597 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y597 D597 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y599 F599 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y599 C599 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K602 I602 Biomuta [ cosmic ]
K614 N614 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R655 G655 Biomuta DOID:1324 / lung cancer [ cosmic ]
R655 K655 Biomuta DOID:4159 / skin cancer [ cosmic ]
S759 L759 Biomuta DOID:4159 / skin cancer [ cosmic ]
K772 N772 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K772 Q772 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S840 Y840 Biomuta DOID:3119 / gastrointestinal system cancer [ cosmic ]
Y842 S842 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y842 C842 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y842 H842 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y955 C955 Biomuta DOID:2998 / testicular cancer [ cosmic ]
R973 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S993 L993 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:2998 / testicular cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]