iPTMnet Report for P35916 (FLT4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35916 / VGFR3_HUMAN
Protein Name Vascular endothelial growth factor receptor 3 precursor
Gene Name Name: FLT4
Synonyms:VEGFR3;
Organism Homo sapiens (Human)

PRO ID PR:P35916
DAG View
PRO Name vascular endothelial growth factor receptor 3 (human)
Definition A vascular endothelial growth factor receptor 3 that is encoded in the genome of human.
Short Label hFLT4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35916 (FLT4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N33 N-Glycosylation GlyGen   UniProt 23878260
N104 N-Glycosylation GlyGen   UniProt 23878260
N411 N-Glycosylation GlyGen   UniProt 23878260
N515 N-Glycosylation GlyGen   UniProt 23878260
T517 Phosphorylation PhosphoSitePlus
N527 N-Glycosylation GlyGen   UniProt 16335952
Y830 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20431062
Y830 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 20431062
Y833 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20431062
Y833 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 20431062
Y853 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20431062
Y853 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 20431062
S863 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
T886 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
Y1063 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16076871, 25003617, 18083107, ...20431062
Y1063 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 20431062
Y1063 Phosphorylation P35916 (FLT4) UniProt 16076871
K1064 Ubiquitination PhosphoSitePlus
Y1068 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 25003617, 16076871, ...20431062
Y1068 Phosphorylation P35916 (FLT4) UniProt 16076871
K1079 Ubiquitination PhosphoSitePlus
S1163 Phosphorylation PhosphoSitePlus
Y1230 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12881528, 16076871, 25643397
Y1230 Phosphorylation P35916 (FLT4) neXtProt   Signor   UniProt 12881528
Y1230 Phosphorylation P35968 (KDR) neXtProt 12881528
Y1231 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 12881528, 16076871
Y1231 Phosphorylation P35916 (FLT4) neXtProt   Signor   UniProt 12881528
Y1231 Phosphorylation P35968 (KDR) neXtProt 12881528
S1235 Phosphorylation PhosphoSitePlus
K1253 Ubiquitination PhosphoSitePlus
Y1265 Phosphorylation neXtProt   Signor   UniProt 12881528
Y1265 Phosphorylation P35916 (FLT4) neXtProt   Signor   UniProt 12881528
Y1265 Phosphorylation P35968 (KDR) neXtProt 12881528
K1300 Ubiquitination PhosphoSitePlus
Y1333 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12881528, 20431062
Y1333 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 20431062
Y1333 Phosphorylation P35916 (FLT4) neXtProt   Signor   UniProt 12881528
Y1333 Phosphorylation P35968 (KDR) neXtProt 12881528
Y1337 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12881528, 7675451, 16076871, ...20431062
Y1337 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 20431062
Y1337 Phosphorylation P35916 (FLT4) neXtProt   Signor   UniProt 12881528
Y1363 Phosphorylation neXtProt   Signor   UniProt 12881528
Y1363 Phosphorylation P35916 (FLT4) neXtProt   Signor   UniProt 12881528
Site PTM Type PTM Enzyme Score Source PMID
T517 Phosphorylation HPRD 20068231
Y532 Phosphorylation HPRD 20068231
Y1230 Phosphorylation HPRD 12881528
Y1231 Phosphorylation HPRD 12881528
Y1265 Phosphorylation HPRD 12881528
Site PTM Type PTM Enzyme Score Source PMID
T517 Phosphorylation HPRD 20068231
Y532 Phosphorylation HPRD 20068231
Y1230 Phosphorylation HPRD 12881528
Y1231 Phosphorylation HPRD 12881528
Y1265 Phosphorylation HPRD 12881528
Y1333 Phosphorylation HPRD 7675451
Y1337 Phosphorylation HPRD 12881528, 7675451
Y1363 Phosphorylation HPRD 12881528, 7675451


P35916 (FLT4) as PTM Enzyme



Substrate Site Score Source PMID
P29353 (SHC1) Y349 phospho.ELM   Signor 9927207
P29353 (SHC1) Y350 phospho.ELM   Signor 9927207
P29353 (SHC1) Y427 phospho.ELM   Signor 9927207
P35916 (FLT4) Y1063 UniProt 16076871
P35916 (FLT4) Y1068 UniProt 16076871
P35916 (FLT4) Y1230 neXtProt   Signor   UniProt 12881528
P35916 (FLT4) Y1231 neXtProt   Signor   UniProt 12881528
P35916 (FLT4) Y1265 neXtProt   Signor   UniProt 12881528
P35916 (FLT4) Y1333 neXtProt   Signor   UniProt 12881528
P35916 (FLT4) Y1337 neXtProt   Signor   UniProt 12881528
P35916 (FLT4) Y1363 neXtProt   Signor   UniProt 12881528
P51812 (RPS6KA3) Y707 Signor 12601080


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N33 D33 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N515 S515 Biomuta DOID:363 / uterine cancer [ cosmic ]
T886 M886 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S986 W986 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y1063 H1063 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1068 * Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
Y1068 C1068 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y1230 H1230 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1235 P1235 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1253 E1253 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1333 H1333 Biomuta DOID:1324 / lung cancer [ cosmic ]