iPTMnet Report for P35570 (Irs1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35570 / IRS1_RAT
Protein Name Insulin receptor substrate 1
Gene Name Name: Irs1
Synonyms:Irs-1;
Organism Rattus norvegicus (Rat)

PRO ID PR:P35570
DAG View
PRO Name insulin receptor substrate 1 (rat)
Definition An insulin receptor substrate 1 that is encoded in the genome of rat.
Short Label rIRS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35570 (Irs1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus   UniProt 22673903
S24 Phosphorylation PhosphoSitePlus   RLIMS-P 15849359
S99 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8349691
S265 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 11287630, 21320568, 17579208
S302 Phosphorylation P42346 (Mtor) Signor 11287630
S302 Phosphorylation Q63644 (Rock1) PhosphoSitePlus 17579208
S307 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 19121314, 17288791, 31766382, ...15297437, 23840732, 17438698, 20459025, 19646964, 19386987, 33497738, 15240096, 24314869, 19781177, 25352752, 19819682, 26433940, 17951543, 24257416, 26455923, 25437926, 15302844, 22362362, 28651236, 16684854, 20307567, 17823255, 29154269, 24460535, 14556646, 15787606, 12006582, 30550886, 27168847, 22314193, 29882093, 19001546, 11160134, 18354292, 16934905, 20946888, 26965244, 30225267, 19686764, 24797633, 11287630, 17403295, 23328071, 20596724, 17570255, 21926342, 17003331, 24389792, 36207218, 21088934, 29036927, 34069933, 25978724, 23715867, 14550547, 29551354, 27185631, 16896943, 27250532, 11606564, 32844579, 21282367, 19728324, 24366086, 21940847, 17728140, 21514684, 29043342, 24788483, 27517611, 19703555, 23840461, 33859259, 26084330, 12510059, 15198936, 24704288
S307 Phosphorylation P42346 (Mtor) Signor 11287630
S307 Phosphorylation P49185 (Mapk8) PhosphoSitePlus   Signor 11606564, 12510059
S310 Phosphorylation Signor 11287630
S310 Phosphorylation P42346 (Mtor) Signor 11287630
K315 Acetylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus   RLIMS-P 15069075, 24797633, 29370351, ...27185631
S318 Phosphorylation P09217 (Prkcz) PhosphoSitePlus 15069075
S324 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus   RLIMS-P 25883115
S336 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus   UniProt 22673903
S345 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus 18285345
S357 Phosphorylation P09215 (Prkcd) PhosphoSitePlus 18285345
S358 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus   RLIMS-P 15485932, 17728140
S414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus   UniProt 22673903
T448 Phosphorylation PhosphoSitePlus   UniProt 22673903
Y460 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 7504175, 7651388
Y460 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus   Signor 7504175, 7651388
S498 Phosphorylation PhosphoSitePlus
T502 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8349691
S522 Phosphorylation PhosphoSitePlus 17579213
S522 Phosphorylation P47196 (Akt1) PhosphoSitePlus 17579213
T525 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25437926, 7504175, 21543456, ...12220227, 24797633, 11416002, 11572799
Y608 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus   Signor 7504175, 11416002, 11572799
Y608 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
S612 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 16940436, 19686764, 11287630, ...27185631, 15134463, 32444657, 26084330, 19171190, 20967757, 24187137
S612 Phosphorylation P05696 (Prkca) PhosphoSitePlus 15134463
S612 Phosphorylation P42346 (Mtor) Signor 11287630
Y628 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   Signor   UniProt 1380456, 11416002, 7504175, ...11572799
Y628 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus   Signor 7504175, 11416002, 11572799
Y628 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
S632 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 16896943, 11287630, 32444657, ...17579208
S632 Phosphorylation P42346 (Mtor) Signor 11287630
S632 Phosphorylation Q63644 (Rock1) PhosphoSitePlus 17579208
S635 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 11287630, 32444657, 17579208
S635 Phosphorylation P42346 (Mtor) Signor 11287630
S635 Phosphorylation Q63644 (Rock1) PhosphoSitePlus 17579208
S637 Phosphorylation PhosphoSitePlus
Y658 Phosphorylation phospho.ELM 11572799
Y658 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
S662 Phosphorylation PhosphoSitePlus
Y727 Phosphorylation phospho.ELM 11572799
Y727 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
S731 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 11287630, 30225267
S731 Phosphorylation P42346 (Mtor) Signor 11287630
S789 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21940847, 12006586, 11598104
S857 Phosphorylation PhosphoSitePlus
S891 Phosphorylation PhosphoSitePlus   UniProt 22673903
Y895 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 7504175, 24797633, 33824679, ...8631859, 8196603, 8491186, 8530377, 16150913
Y895 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus 7504175, 8196603, 8530377
Y895 Phosphorylation P24062 (Igf1r) phospho.ELM 8530377
S914 O-Glycosylation GlyGen   PhosphoSitePlus 16000877, 19671924, 16244361
Y939 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 7504175, 7651388, 11572799
Y939 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus   Signor 7504175, 7651388, 11572799
Y939 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
Y987 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 7504175, 7651388, 11572799
Y987 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus   Signor 7504175, 7651388, 11572799
Y987 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
S1003 Phosphorylation PhosphoSitePlus
S1009 O-Glycosylation GlyGen   PhosphoSitePlus 19671924
S1036 O-Glycosylation GlyGen   PhosphoSitePlus 16000877, 19671924, 16244361
S1041 O-Glycosylation GlyGen   PhosphoSitePlus 16000877, 19671924, 16244361
T1045 Phosphorylation PhosphoSitePlus
S1077 Phosphorylation PhosphoSitePlus
S1099 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus   RLIMS-P 25437926, 32444657
T1102 Phosphorylation PhosphoSitePlus
T1107 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
Y1172 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   UniProt 7504175, 8631859, 11572799
Y1172 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus 7504175, 11572799
Y1172 Phosphorylation P24062 (Igf1r) phospho.ELM 11572799
S1215 Phosphorylation PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
Y1222 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 7504175, 12220227
Y1222 Phosphorylation P15127 (Insr) phospho.ELM   PhosphoSitePlus 7504175