iPTMnet Report for P35569 (Irs1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35569 / IRS1_MOUSE
Protein Name Insulin receptor substrate 1
Gene Name Name: Irs1
Synonyms:Irs-1;
Organism Mus musculus (Mouse)

PRO ID PR:P35569
DAG View
PRO Name insulin receptor substrate 1 (mouse)
Definition An insulin receptor substrate 1 that is encoded in the genome of mouse.
Short Label mIRS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35569 (Irs1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation phospho.ELM   PhosphoSitePlus 17242355
T7 Phosphorylation PhosphoSitePlus
S24 Phosphorylation Q62406 (Irak1) RLIMS-P+   RLIMS-P 19675138, 15849359
Y46 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S267 Phosphorylation phospho.ELM   PhosphoSitePlus 12714600
S268 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
S302 Phosphorylation Q8BSK8 (Rps6kb1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 29364220, 32921413, 25381390, ...11701324, 30050584, 15306821
T306 Phosphorylation PhosphoSitePlus
S307 Phosphorylation Q91Y86 (Mapk8) , Q60680 (Chuk) , Q03963 (Eif2ak2) phospho.ELM   PhosphoSitePlus   RLIMS-P 26720454, 26666849, 25381390, ...29497383, 17575262, 28866332, 32703455, 19564410, 26400768, 22832498, 25594850, 23667647, 33303821, 12417588, 18036196, 15314024, 26836389, 30030460, 28919555, 29490521, 15994203, 25141786, 20185762, 15982669, 29339083, 15925330, 22733784, 30050584, 31233775, 32714408, 24855642, 22948222, 21386087, 24002347, 27702567, 35739993, 18796617, 16469808, 14998989, 26882989, 26112408, 14579029, 22942720, 26450947, 21731668, 16998818, 22307032, 21447485, 29433422, 19587264, 35111058, 26474286, 20144759, 28867797, 12714600, 32692982, 20587749, 32664532, 11160134, 35842638, 18721257, 28708100, 19234595, 16055440, 30972066, 22828956, 15143153, 29736736, 24966659, 24333417, 25826740, 30023489, 35508278, 20388826, 29988567, 26023930, 18296638, 35940125, 22191431, 33011364, 29440699, 26454089, 20813836, 22454293, 30324688, 21756814, 16777975
S310 Phosphorylation PhosphoSitePlus
S318 Phosphorylation P28867 (Prkcd) phospho.ELM   PhosphoSitePlus   RLIMS-P 16129678, 35508278, 16418171, ...16099431, 31616027, 16055440
S324 Phosphorylation phospho.ELM 17242355
S325 Phosphorylation PhosphoSitePlus   UniProt 21183079
S332 Phosphorylation PhosphoSitePlus   RLIMS-P 18430969
S336 Phosphorylation P20444 (Prkca) PhosphoSitePlus   RLIMS-P+ 18430969
S340 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17242355
S343 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S408 Phosphorylation phospho.ELM   PhosphoSitePlus 15485932
S412 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus   UniProt 21183079
S422 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
Y478 Phosphorylation PhosphoSitePlus
T520 Phosphorylation PhosphoSitePlus
S522 Phosphorylation Q8BSK8 (Rps6kb1) PhosphoSitePlus   Signor 18498745
T525 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 22418434, 19546233, 22289908, ...26491103, 25689493, 15821749, 24435134, 19675138, 9395471, 26023930, 26882989, 21386087
S612 Phosphorylation Q99MK8 (Grk2) , Q63844 (Mapk3) , P63085 (Mapk1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24763529, 24159000, 10092613, ...26512886, 12917346, 33062046, 14579029, 35508278, 26474286, 15821749, 23301857, 9395471, 24187137, 15994203, 27819676, 21386087
Y628 Phosphorylation PhosphoSitePlus   RLIMS-P 24763529
S632 Phosphorylation P70336 (Rock2) , Q8BSK8 (Rps6kb1) , Q9JLN9 (Mtor) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14579029, 11287630, 16098829, ...19276091, 15306821, 21386087
S635 Phosphorylation Q99MK8 (Grk2) , Q9JLN9 (Mtor) , P70336 (Rock2) , Q8BSK8 (Rps6kb1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 11287630, 16098829, 18498745, ...19276091, 15994203, 15306821
S637 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S676 Phosphorylation RLIMS-P 22418434
S731 Phosphorylation Q8BSK8 (Rps6kb1) PhosphoSitePlus   Signor 15306821
S761 Phosphorylation PhosphoSitePlus
S789 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11598104, 22906703
T854 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus   UniProt 21183079
Y891 Phosphorylation PhosphoSitePlus
Y935 Phosphorylation PhosphoSitePlus
S966 O-Glycosylation GlyGen 32782141
Y983 Phosphorylation PhosphoSitePlus
S999 Phosphorylation PhosphoSitePlus
S1074 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus   UniProt 21183079
S1097 Phosphorylation Q02111 (Prkcq) , Q8BSK8 (Rps6kb1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22418434, 21183079, 17242355, ...15364919, 15306821
T1099 Phosphorylation PhosphoSitePlus
S1101 Phosphorylation RLIMS-P 17709744, 26474286, 29496905, ...20921627, 27872488, 32998286
T1104 Phosphorylation PhosphoSitePlus
S1136 Phosphorylation PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
S1139 Phosphorylation phospho.ELM   PhosphoSitePlus 17242355
S1170 Phosphorylation PhosphoSitePlus
Y1173 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
S1213 Phosphorylation PhosphoSitePlus
S1214 Phosphorylation phospho.ELM   PhosphoSitePlus 17242355
S1218 Phosphorylation PhosphoSitePlus
Y1220 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P39688 (Fyn) Y531 P35569 (Irs1) increased_association eFIP 8631859