iPTMnet Report P35269 GTF2F1

Protein Information

UniProt AC / UniProt ID	P35269 / T2FA_HUMAN
Protein Name	General transcription factor IIF subunit 1
Gene Name	Name: GTF2F1 Synonyms:RAP74;
Organism	Homo sapiens (Human)

PRO ID	PR:P35269 DAG View
PRO Name	general transcription factor IIF subunit 1 (human)
Definition	A general transcription factor IIF subunit 1 that is encoded in the genome of human.
Short Label	hGTF2F1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P35269 (GTF2F1) as Substrate

P35269

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
A2	Acetylation		score1	UniProt	19413330, 22814378, 22223895
Y14	Phosphorylation		score0	HPRD	20068231
K55	Ubiquitination		score1	PhosphoSitePlus
Y57	Phosphorylation		score1	PhosphoSitePlus
K83	Ubiquitination		score1	PhosphoSitePlus
K89	Ubiquitination		score1	PhosphoSitePlus
T154	Phosphorylation		score1	PhosphoSitePlus
T156	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K169	Ubiquitination		score1	PhosphoSitePlus
K183	Ubiquitination		score1	PhosphoSitePlus
S203	Phosphorylation		score1	PhosphoSitePlus
S217	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	21406692, 16083285, 17081983, ...18452278, 19651622, 18669648, 19690332, 20068231
S218	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	21406692, 16083285, 17081983, ...18452278, 19651622, 18669648, 20068231
S221	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	16083285, 17081983, 18452278, ...19651622, 18669648, 20068231
S224	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	21406692, 17081983, 18452278, ...19651622, 18669648, 20068231
S253	Phosphorylation		score2	HPRD PhosphoSitePlus	18452278
S261	Phosphorylation		score1	PhosphoSitePlus
S305	Phosphorylation		score2	HPRD PhosphoSitePlus	19651622, 17081983, 20068231, ...18452278
S307	Phosphorylation		score2	HPRD PhosphoSitePlus	19651622, 17081983, 20068231, ...18452278
S308	Phosphorylation		score2	HPRD PhosphoSitePlus	19651622, 17081983, 20068231, ...18452278
S311	Phosphorylation		score2	HPRD PhosphoSitePlus	19651622, 17081983, 20068231, ...18452278
K315	Acetylation		score1	PhosphoSitePlus
K328	Acetylation		score1	PhosphoSitePlus
T331	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	19651622, 21406692, 20068231
S341	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 18452278
S342	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 18452278
S345	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 18452278
S347	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 18452278
S348	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 18452278
S351	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	17081983, 18452278
S355	Phosphorylation		score2	HPRD PhosphoSitePlus	18452278
T368	Phosphorylation		score1	PhosphoSitePlus
S377	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S380	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648
S381	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648
S385	Phosphorylation	P35269 (GTF2F1)	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	19413330, 21406692, 23186163, ...16964243, 18220336, 10428810, 19664994, 19664995, 19651622, 18669648, 19690332, 20068231
T389	Phosphorylation	P35269 (GTF2F1)	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	19413330, 23186163, 16964243, ...18220336, 10428810, 19664994, 19664995, 19651622, 18669648, 19690332, 20068231
S391	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 19651622, 18669648, ...21406692
S396	Phosphorylation		score1	PhosphoSitePlus
T397	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
S398	Phosphorylation		score1	PhosphoSitePlus
S399	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18220336
K407	Acetylation		score2	PhosphoSitePlus UniProt	19608861
K412	Acetylation		score1	PhosphoSitePlus
S415	Phosphorylation		score1	PhosphoSitePlus
K421	Acetylation		score1	PhosphoSitePlus
T427	Phosphorylation		score1	PhosphoSitePlus
S431	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	23186163, 18669648, 20058876, ...18212344
S433	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	23186163, 16964243, 20058876, ...18669648, 20068231, 17924679
S436	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648
T437	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S442	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	19413330, 18669648, 20068231
K444	Ubiquitination		score1	PhosphoSitePlus
T445	Phosphorylation	P24941 (CDK2)	score2	HPRD phospho.ELM PhosphoSitePlus	19413330, 18669648, 18847512, ...20068231
T446	Phosphorylation	P24941 (CDK2)	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648, 18847512, 20068231, ...18452278
S449	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648
T455	Phosphorylation		score1	PhosphoSitePlus
K466	Acetylation		score1	PhosphoSitePlus
K471	Acetylation		score1	PhosphoSitePlus
T482	Phosphorylation		score0	HPRD	20068231
T489	Phosphorylation		score0	HPRD	20068231
K510	Ubiquitination		score1	PhosphoSitePlus

P35269 (GTF2F1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P13631 (RARG)	S77	score2	PhosphoSitePlus	10748061
P13631 (RARG)	S79	score2	PhosphoSitePlus	10748061
P35269 (GTF2F1)	S385	score3	PhosphoSitePlus Signor	10428810
P35269 (GTF2F1)	T389	score3	PhosphoSitePlus Signor	10428810

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
A2	T2	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
A2	S2	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S217	L217	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S224	I224	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S345	L345	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S355	N355	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T368	M368	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S377	L377	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S381	P381	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S381	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T389	M389	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T397	I397	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S436	L436	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S442	L442	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T446	I446	Biomuta	[ cosmic ]
S449	N449	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P35269 (GTF2F1)

Protein Information

Interactive Sequence View

P35269 (GTF2F1) as Substrate

P35269 (GTF2F1) as PTM Enzyme

PTM sites affected in variants