iPTMnet Report for P35268 (RPL22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35268 / RL22_HUMAN
Protein Name Large ribosomal subunit protein eL22
Gene Name Name: RPL22
Organism Homo sapiens (Human)

PRO ID PR:P35268
DAG View
PRO Name 60S ribosomal protein L22 (human)
Definition A 60S ribosomal protein L22 that is encoded in the genome of human.
Short Label hRPL22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35268 (RPL22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Acetylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus   UniProt 23186163
S68 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K80 Methylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
R101 Methylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 I48 Biomuta DOID:3571 / liver cancer [ cosmic ]
S68 N68 Biomuta DOID:4159 / skin cancer [ cosmic ]
S74 F74 Biomuta DOID:4159 / skin cancer [ cosmic ]
S79 F79 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K84 T84 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R101 H101 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R101 C101 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]