iPTMnet Report for P35249 (RFC4)
Protein Information
UniProt AC / UniProt ID | P35249 / RFC4_HUMAN |
Protein Name | Replication factor C subunit 4 |
Gene Name | Name: RFC4 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P35249 |
PRO Name | replication factor C subunit 4 (human) |
Definition | A replication factor C subunit 4 that is encoded in the genome of human. |
Short Label | hRFC4 |
Category | organism-gene |
P35249 (RFC4) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22814378 | ||
K6 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K6 | Methylation | score1 | PhosphoSitePlus | |||
K6 | Ubiquitination | score1 | PhosphoSitePlus | |||
S9 | Phosphorylation | score1 | PhosphoSitePlus | |||
S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
K13 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
T17 | Phosphorylation | score1 | PhosphoSitePlus | |||
K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
R20 | Methylation | score1 | PhosphoSitePlus | |||
S25 | Phosphorylation | score1 | PhosphoSitePlus | |||
S28 | Phosphorylation | score1 | PhosphoSitePlus | |||
S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
K43 | Ubiquitination | score1 | PhosphoSitePlus | |||
K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
C48 | Methylation | score1 | IEDB | 31844290 | ||
K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
R114 | Methylation | score1 | PhosphoSitePlus | |||
K124 | Ubiquitination | score1 | PhosphoSitePlus | |||
K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
T166 | Phosphorylation | score1 | PhosphoSitePlus | |||
T174 | Phosphorylation | score1 | PhosphoSitePlus | |||
S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
T191 | Phosphorylation | score1 | PhosphoSitePlus | |||
S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
K216 | Acetylation | score1 | PhosphoSitePlus | |||
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
K217 | Acetylation | score1 | PhosphoSitePlus | |||
K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
T252 | O-Glycosylation | score1 | GlyGen | 23301498, 33214551, 30379171, ... | ||
K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
C281 | Methylation | score1 | IEDB | 31844290 | ||
S285 | Phosphorylation | score1 | PhosphoSitePlus | |||
K288 | Ubiquitination | score1 | PhosphoSitePlus | |||
K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
K322 | Ubiquitination | score1 | PhosphoSitePlus | |||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
C337 | Methylation | score1 | IEDB | 31844290 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S9 | A9 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S9 | P9 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T17 | S17 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc, tcga ] | |
R20 | L20 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S25 | G25 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K63 | N63 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
K64 | T64 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K84 | N84 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K139 | T139 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K200 | N200 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K232 | E232 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K232 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S285 | C285 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K324 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K324 | E324 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |