iPTMnet Report for P35221 (CTNNA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35221 / CTNA1_HUMAN
Protein Name Catenin alpha-1
Gene Name Name: CTNNA1
Organism Homo sapiens (Human)

PRO ID PR:P35221
DAG View
PRO Name catenin alpha-1 (human)
Definition A catenin alpha-1 that is encoded in the genome of human.
Short Label hCTNNA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35221 (CTNNA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
R165 Methylation PhosphoSitePlus
Y177 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K178 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus   UniProt 24275569
S268 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y280 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus   UniProt 24275569
S297 Phosphorylation PhosphoSitePlus   UniProt 24275569
S304 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
C337 Methylation IEDB 33981976
S361 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
C461 Methylation IEDB 31844290
S477 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y619 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T634 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 24275569
S641 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 19369195, 21406692, 23186163, ...17081983, 18220336, 16807684, 15302935, 18318008, 18669648, 19941816, 24275569, 25653389, 19690332, 20068231
T645 Phosphorylation PhosphoSitePlus   UniProt 18318008
S652 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 25653389, 21406692, ...17487921
T654 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S655 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 25653389
T658 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 25653389
S668 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
K697 Acetylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
K747 Acetylation PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
C767 S-Nitrosylation dbSNO 2212679, 22126794
S770 Phosphorylation PhosphoSitePlus
C772 S-Nitrosylation dbSNO 2212679, 22126794
K773 Ubiquitination PhosphoSitePlus
Y779 Phosphorylation PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
Y837 Phosphorylation PhosphoSitePlus
K842 Acetylation PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus   UniProt 24275569
S858 Phosphorylation PhosphoSitePlus
T878 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...33465208
S886 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
K901 Methylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y177 Phosphorylation HPRD 18083107
Y619 Phosphorylation HPRD 18083107
T634 Phosphorylation HPRD 18578522, 19664995, 19651622, ...18669648, 20166139, 20068231
S641 Phosphorylation HPRD 19413330, 18578522, 18491316, ...20058876, 19664994, 19664995, 18452278, 19651622, 15302935, 18669648, 20166139, 19415658, 20068231
T645 Phosphorylation HPRD 18452278
S652 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20166139
T654 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20166139
S655 Phosphorylation HPRD 19413330, 19664994, 19651622, ...18669648, 20166139, 20068230
T658 Phosphorylation HPRD 19413330, 19664994, 19651622, ...18669648, 20166139, 15345747, 19415658


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K16 E16 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y148 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y148 S148 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y222 C222 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y237 C237 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K246 R246 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S264 L264 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S268 L268 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S311 G311 Biomuta DOID:1324 / lung cancer [ cosmic ]
S323 P323 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S393 Y393 Biomuta DOID:363 / uterine cancer [ icgc ]
K448 T448 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S453 F453 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T541 A541 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y563 C563 Biomuta [ cosmic ]
T654 M654 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K737 E737 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C767 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S770 L770 Biomuta DOID:2394 / ovarian cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
C772 R772 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y779 H779 Biomuta DOID:4159 / skin cancer [ cosmic ]
S846 P846 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S851 Y851 Biomuta DOID:1324 / lung cancer [ icgc ]
S851 F851 Biomuta DOID:1324 / lung cancer [ cosmic ]
S898 R898 Biomuta DOID:10283 / prostate cancer [ icgc ]