iPTMnet Report for P34949 (MPI)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P34949 / MPI_HUMAN
Protein Name Mannose-6-phosphate isomerase
Gene Name Name: MPI
Synonyms:PMI1;
Organism Homo sapiens (Human)

PRO ID PR:P34949
DAG View
PRO Name mannose-6-phosphate isomerase (human)
Definition A mannose-6-phosphate isomerase that is encoded in the genome of human.
Short Label hMPI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34949 (MPI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K44 Ubiquitination PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
R65 Methylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus   UniProt 24275569
S108 Phosphorylation PhosphoSitePlus   UniProt 24275569
K115 Ubiquitination PhosphoSitePlus
K163 Sumoylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
C251 Methylation IEDB 31844290
K320 Ubiquitination PhosphoSitePlus
R322 Methylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K60 N60 Biomuta DOID:363 / uterine cancer [ icgc ]
R65 H65 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S102 L102 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S102 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K218 N218 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C251 Y251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C251 W251 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S366 C366 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]