iPTMnet Report for P34741 (SDC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P34741 / SDC2_HUMAN
Protein Name Syndecan-2 precursor
Gene Name Name: SDC2
Synonyms:HSPG1;
Organism Homo sapiens (Human)

PRO ID PR:P34741
DAG View
PRO Name syndecan-2 (human)
Definition A syndecan-2 that is encoded in the genome of human.
Short Label hSDC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34741 (SDC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation PhosphoSitePlus
T80 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S81 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T88 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
T89 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T90 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T101 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 22171320
T107 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S115 Phosphorylation PhosphoSitePlus   UniProt 26091039
K174 Ubiquitination PhosphoSitePlus
Y179 Phosphorylation P12931 (SRC) PRO   PhosphoSitePlus 16997272
R184 Methylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S187 Phosphorylation P05129 (PRKCG) , P17252 (PRKCA) , P05771 (PRKCB) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 21406692, 9244383
S188 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus 19901323, 9244383
Y191 Phosphorylation HPRD   PRO   PhosphoSitePlus 19901323
K193 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y200 Phosphorylation HPRD   PhosphoSitePlus 19901323


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049174 (hSDC2/SigPep-/Phos:1) pY179,pY191 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T80 S80 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S81 R81 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T88 I88 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T89 M89 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T90 M90 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T107 I107 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S115 Y115 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S115 C115 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y179 N179 Biomuta DOID:3571 / liver cancer [ cosmic ]
R184 C184 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S188 R188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T196 I196 Biomuta DOID:3571 / liver cancer [ cosmic ]